Genome-wide identification of molecular mimicry candidates in parasites (Publications)
Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimic
Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter? (Publications)
The World Health Organization (WHO) assigns high priority to the prevention of non-communicable age-related diseases such as heart disease, cancer, diabetes, stroke and chronic lower respiratory disea
Reduced risk of <em>Plasmodium vivax</em> malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control... (Publications)
BACKGROUND: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Delta27) protects against cerebral malari
The elusive meningococcal meningitis serogroup: a systematic review of serogroup B epidemiology (Publications)
BACKGROUND: Invasive meningococcal disease (IMD), is a widely distributed, complex human disease affecting all age categories. The causative agent, Neisseria meningitidis, is spread through aerosol re
Advancing drug innovation for neglected diseases-criteria for lead progression (Publications)
The current drug R&D pipeline for most neglected diseases remains weak, and unlikely to support registration of novel drug classes that meet desired target product profiles in the short term. This cal
Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
BACKGROUND: Trials of intermittent preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness
Schistosomiasis, soil-transmitted helminthiasis, and sociodemographic factors influence quality of life of adults in Côte d'Ivoire (Publications)
BACKGROUND: Burden of disease estimates are widely used for priority setting in public health and disability-adjusted life years are a powerful "currency" nowadays. However, disability weights, which