Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness (Publications)
BACKGROUND: Human African trypanosomiasis (HAT), also known as sleeping sickness, is a fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are scarce, toxic, no longer ef
Major surface glycoproteins of insect forms of <em>Trypanosoma brucei</em> are not essential for cyclical transmission by tsetse (Publications)
Procyclic forms of Trypanosoma brucei reside in the midgut of tsetse flies where they are covered by several million copies of glycosylphosphatidylinositol-anchored proteins known as procyclins. It ha
A research agenda for malaria eradication: cross-cutting issues for eradication (Publications)
Discipline-specific Malaria Eradication Research Agenda (malERA) Consultative Groups have recognized several cross-cutting issues that must be addressed to prevent repetition of some of the mistakes o
Costs and consequences of large-scale vector control for malaria (Publications)
BACKGROUND: Five large insecticide-treated net (ITN) programmes and two indoor residual spraying (IRS) programmes were compared using a standardized costing methodology. METHODS: Costs were measured l
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease (Publications)
In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used
Rapid urban malaria appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan) (Publications)
BACKGROUND: Currently, there is a significant lack of knowledge concerning urban malaria patterns in general and in Abidjan in particular. The prevalence of malaria, its distribution in the city and t
Secondary bacterial infections of Buruli ulcer lesions before and after chemotherapy with Streptomycin and Rifampicin (Publications)
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast b
A research agenda for malaria eradication: modeling (Publications)
Malaria modeling can inform policy and guide research for malaria elimination and eradication from local implementation to global policy. A research and development agenda for malaria modeling is prop