Bis(oxyphenylene)benzimidazoles: a novel class of anti-<em>Plasmodium falciparum</em> agents (Publications)
A small library of 26 2,2'-[alkane-alpha,omega-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhode
Dog ownership enhances symptomatic responses to air pollution in children with asthma (Publications)
BACKGROUND: Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence.
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of <em>Trypanosoma cruzi </em>dUTPase (Publications)
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using s
Traffic, susceptibility, and childhood asthma (Publications)
Results from studies of traffic and childhood asthma have been inconsistent, but there has been little systematic evaluation of susceptible subgroups. In this study, we examined the relationship of lo
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently availabl
Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of <em>Plasmodium... (Publications)
Apical membrane antigen 1 (AMA-1) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. Its ectodomain can be divided into three subdomains, each with dis
Effect of fireworks events on urban background trace metal aerosol concentrations: is the cocktail worth the show? (Publications)
We report on the effect of a major firework event on urban background atmospheric PM(2.5) chemistry, using 24-h data collected over 8 weeks at two sites in Girona, Spain. The firework pollution episod
Bayesian analysis of zero inflated spatiotemporal HIV/TB child mortality data through the INLA and SPDE approaches: applied to data observed between... (Publications)
Longitudinal mortality data with few deaths usually have problems of zero-inflation. This paper presents and applies two Bayesian models which cater for zero-inflation, spatial and temporal random eff