Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the <em>Trypanosoma brucei</em> complex (Publications)
The Trypanosoma brucei complex contains a number of subspecies with exceptionally variable life histories, including zoonotic subspecies, which are causative agents of human African trypanosomiasis (H
Uptake of guidelines on prevention of mother-to-child transmission of HIV in rural Tanzania: time for change (Publications)
Guidelines on prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) are inconsistently implemented in low-income countries. Strategies are needed to improve the upta
1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro (Publications)
A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma bruc
Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia (Publications)
Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the 2 disease manifest
Global phylogenomic analysis of nonencapsulated <em>Streptococcus pneumoniae</em> reveals a deep-branching classic lineage that is distinct from... (Publications)
The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated Streptococcus pne
Zoonotic <em>Mycobacterium bovis</em> - induced tuberculosis in humans (Publications)
We aimed to estimate the global occurrence of zoonotic tuberculosis (TB) caused by Mycobacterium bovis or M. caprae infections in humans by performing a multilingual, systematic review and analysis of
Essential evidence for guiding health system priorities and policies: anticipating epidemiological transition in Africa (Publications)
Background: Despite indications that infection-related mortality in sub-Saharan Africa may be decreasing and the burden of non-communicable diseases increasing, the overwhelming reality is that health
Estimating population and livestock density of mobile pastoralists and sedentary settlements in the south-eastern Lake Chad area (Publications)
Mobile pastoralists provide major contributions to the gross domestic product in Chad, but little information is available regarding their demography. The Lake Chad area population is increasing, resu
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion (Publications)
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50?0.5 µM), and was posited to exploit the physiological differen
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products (Publications)
Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis.