Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis (Publications)
Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid.
Diversity of exophillic acid derivatives in strains of an endophytic <em>Exophiala</em> sp. (Publications)
Members of the fungal genus Exophiala are common saprobes in soil and water environments, opportunistic pathogens of animals, or endophytes in plant roots. Their ecological versatility could imply a c
Antimalarial benzoheterocyclic 4-aminoquinolines: structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies (Publications)
A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resist
Health impacts of anthropogenic biomass burning in the developed world (Publications)
Climate change policies have stimulated a shift towards renewable energy sources such as biomass. The economic crisis of 2008 has also increased the practice of household biomass burning as it is ofte
Discovery of inhibitors of<em> Trypanosoma brucei</em> by phenotypic screening of a focused protein kinase library (Publications)
A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed > 50 % inhibition at 5 muM. Screen
