Acute schistosomiasis: a risk underestimated by travelers and a diagnosis frequently missed by general practioners - a cluster analysis of 42... (Publications)
BACKGROUND: In 2011, a patient was admitted to our hospital with acute schistosomiasis after having returned from Madagascar and having bathed at the Lily waterfalls. On the basis of this patient's in
Regional differences of physical activity and sedentary behaviour in Swiss children are not explained by socio-demographics or the built environment (Publications)
OBJECTIVE: We evaluated whether regional differences in physical activity (PA) and sedentary behaviour (SB) existed along language boundaries within Switzerland and whether potential differences would
Maximizing microscopy as a diagnostic tool in peripheral health centres of BU endemic areas in Ghana (Publications)
BACKGROUND: Buruli ulcer (BU) disease, a skin condition caused by Mycobacterium ulcerans (M. ulcerans) is endemic in remote rural areas. Disease diagnosis on clinical basis alone can be misleading, re
Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action [Communication] (Publications)
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoa
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in co
Southern East Asian origin and coexpansion of <em>Mycobacterium tuberculosis</em> Beijing family with Han Chinese (Publications)
The Beijing family is the most successful genotype of Mycobacterium tuberculosis and responsible for more than a quarter of the global tuberculosis epidemic. As the predominant genotype in East Asia,
Microbial and chemical contamination of water, sediment and soil in the Nakivubo wetland area in Kampala, Uganda (Publications)
The reuse of domestic and industrial wastewater in urban settings of the developing world may harm the health of people through direct contact or via contaminated urban agricultural products and drink
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
BACKGROUND: The efficacy and safety of the RTS,S/AS01 candidate malaria vaccine during 18 months of follow-up have been published previously. Herein, we report the final results from the same trial, i
<em>In vivo</em> biosynthesis of terpene nucleosides provides unique chemical markers of <em>Mycobacterium tuberculosis</em> infection (Publications)
Although small molecules shed from pathogens are widely used to diagnose infection, such tests have not been widely implemented for tuberculosis. Here we show that the recently identified compound, 1-
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
BACKGROUND: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing s
