Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to <em>Mycobacterium... (Publications)
Mycolactone is an immunosuppressive cytotoxin responsible for the clinical manifestation of Buruli ulcer in humans. It was believed to be confined to its etiologic agent, Mycobacterium ulcerans. Howev
Research capacity strengthening in low and middle income countries - an evaluation of the WHO/TDR career development fellowship programme (Publications)
Between August 2012 and April 2013 the Career Development Fellowship programme of the Special Programme for Research and Training in Tropical Diseases (World Health Organization) underwent an external
Independent loss of immunogenic proteins in <em>Mycobacterium ulcerans</em> suggests immune evasion (Publications)
The highly immunogenic mycobacterial proteins ESAT-6, CFP-10, and HspX represent potential target antigens for the development of subunit vaccines and immunodiagnostic tests. Recently, the complete ge
Risk factors for Buruli ulcer in Ghana - a case control study in the Suhum-Kraboa-Coaltar and Akuapem south districts of the eastern region (Publications)
BACKGROUND: Buruli ulcer (BU) is a skin disease caused by Mycobacterium ulcerans. Its exact mode of transmission is not known. Previous studies have identified demographic, socio-economic, health and
AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis (Publications)
An ubiquitous and conserved proteolytic system regulates the stability of mitochondrial inner membrane proteins. Two AAA proteases with catalytic sites at opposite membrane surfaces form a membrane-in
Arginine and lysine transporters are essential for <em>Trypanosoma brucei</em> (Publications)
For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have to be imported from the host. Heterologous expression in Saccharomyces cerevisiae mutants identified cationic am
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have b