Efficacy and tolerability of quinacrine monotherapy and albendazole plus chloroquine combination therapy in nitroimidazole-refractory giardiasis: a... (Publications)
data on the efficacy and tolerability of 2 second-line treatment regimens. METHODS: This prospective, open-label, multicenter study assessed the efficacy and tolerability of quinacrine monotherapy (100 mg
Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
readily available S-(+)- and R-(-)-citronellene respectively. Subsequently, we have answered a still open question, i.e. specificity of artemisinins action. Using a drug sensitive Plasmodium falc. NF54 strain
MMC elimination costing (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/mmc-elimination-costing
for a number of policy relevant scenarios simulated with a simulation model of malaria dyanamics (OpenMalaria), (3) synthesis of costing and modeling estimatesfor resource allocation decisions by stakeholders
Efficacy and tolerability of quinacrine monotherapy and albendazole plus chloroquine combination therapy in nitroimidazole-refractory giardiasis: a... (Publications)
data on the efficacy and tolerability of 2 second-line treatment regimens. METHODS: This prospective, open-label, multicenter study assessed the efficacy and tolerability of quinacrine monotherapy (100 mg
Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)
readily available S-(+)- and R-(-)-citronellene respectively. Subsequently, we have answered a still open question, i.e. specificity of artemisinins action. Using a drug sensitive Plasmodium falc. NF54 strain
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the Swiss TPH and collaborators. OpenMalaria has been developed as a decision-making support tool
Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside (Publications)
in the absence of experimentally increased intracellular Ca2+, suggesting that emodepside directly opens C. elegans Slo-1a. Emodepside wash-out did not reverse the effect and the Slo-1 inhibitor verruculogen [...] properties among species. Most importantly, this study showed for the first time that emodepside directly opens a Slo-1 channel, significantly improving the understanding of the mode of action of this drug class
Building-related health impacts in European and Chinese cities: a scalable assessment method (Publications)
impacts, both positive and negative, on public health. Our main objective was to develop a generic open impact model to estimate health impacts of emissions due to heat and power consumption of buildings [...] and large impacts on emissions. However, the life cycle impacts of different fuels is somewhat an open question. CONCLUSIONS: In conclusion, we were able to develop a practical model for city-level assessments
Country modelling to support National Malaria Control Programs - High Burden to High Impact (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/country-modelling-to-support-national-malaria-control-programs-high-burden-to-high-impact
of malaria-related interventions. Our work is based on the OpenMalaria modelling platform developed by the Swiss TPH and collaborators. OpenMalaria has been developed as a decision-making support tool
Modelling support to decision-making for malaria control in Benin (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/modelling-support-to-decision-making-for-malaria-control-in-benin
to gather a deeper understanding of the past malaria burden and control efforts. We then calibrate OpenMalaria , the malaria transmission simulation platform developed in-house, to quantify the transmission [...] malaria chemoprevention to children until 10 in few regions or until 5 in a larger area. We use again OpenMalaria to project the impact of the interventions on prevalence, incidence and severe cases. We provide
