Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity (Publications)
3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial
Travel medicine and mHealth technology: a study using smartphones to collect health data during travel (Publications)
BACKGROUND: mHealth methodology such as smartphone applications offers new opportunities to capture the full range of health risks during travel in real time. Our study aims to widen the scope of trav
Hemolysis after oral artemisinin combination therapy for uncomplicated <em>Plasmodium falciparum</em> malaria (Publications)
Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective observational study of patients with uncomplicated
The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes (Publications)
3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side chains, being part of drugs in use, to the ring nitrog
Community co-designed schistosomiasis control interventions for school-aged children in Zanzibar (Publications)
Top-down biomedical interventions to control schistosomiasis in sub-Saharan Africa have had limited success, primarily because they fail to engage with the social, political, economic and ecological c
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is th
Pregnant women and infants as sentinel populations to monitor prevalence of malaria: results of pilot study in Lake Zone of Tanzania (Publications)
BACKGROUND: As malaria control interventions are scaled-up, rational approaches are needed for monitoring impact over time. One proposed approach includes monitoring the prevalence of malaria infectio
Home-based and facility-based directly observed therapy of tuberculosis treatment under programmatic conditions in urban Tanzania (Publications)
INTRODUCTION: Decentralization of Directly Observed Treatment (DOT) for tuberculosis (TB) to the community (home-based DOT) has improved the coverage of TB treatment and reduced the burden to the heal
Spatiotemporal co-existence of two <em>Mycobacterium ulcerans</em> clonal complexes in the Offin River valley of Ghana (Publications)
In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely
Assessing stool quantities generated by three specific Kato-Katz thick smear templates employed in different settings (Publications)
BACKGROUND: The Kato-Katz technique is recommended for the diagnosis of helminth infections in epidemiological surveys, drug efficacy studies and monitoring of control interventions. We assessed the c
