Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction (Publications)
RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perfor
Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from... (Publications)
Total serum IgE, Phadiatop, and the skin prick test (SPT) are commonly used to diagnose atopic diseases. However, no large study has ever been done to test their diagnostic efficiency. We studied the
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently availa
Using the COMMVAC taxonomy to map vaccination communication interventions in Mozambique (Publications)
BACKGROUND: Improved communication about childhood vaccination is fundamental to increasing vaccine uptake in low-income countries. Mozambique, with 64% of children fully vaccinated, uses a range of c
Healthy lifestyle and heart rate variability in young adults (Publications)
BACKGROUND: We aimed to determine the association of a comprehensive healthy lifestyle with heart rate variability (HRV), a validated measure of autonomic function. DESIGN: This was a prospective coho
Transient hyperglycemia in patients with tuberculosis in Tanzania: implications for diabetes screening algorithms (Publications)
BACKGROUND: Diabetes mellitus (DM) increases tuberculosis (TB) risk while TB, as an infectious disease, leads to hyperglycemia. We compared hyperglycemia screening strategies in controls and TB patien
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation (Publications)
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1
40 years of progress in female cancer death risk: a Bayesian spatio-temporal mapping analysis in Switzerland (Publications)
BACKGROUND: In the past decades, mortality of female gender related cancers declined in Switzerland and other developed countries. Differences in the decrease and in spatial patterns within Switzerlan
