Premature atrial contractions in the general population: frequency and risk factors (Publications)
BACKGROUND: Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke and death. However, little is known about PAC frequency in the general population and its ass
Land use regression models for crustal and traffic-related PM2.5 constituents in four areas of the SAPALDIA study (Publications)
Many studies have documented adverse health effects of long-term exposure to fine particulate matter (PM2.5), but there is still limited knowledge regarding the causal relationship between specific so
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order (Publications)
BACKGROUND: Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There
Genetic heterogeneity of asthma phenotypes identified by a clustering approach (Publications)
The aim was to identify genetic variants associated with refined asthma phenotypes enabling to take into account multiple features of the disease.Latent class analysis (LCA) was applied in 3001 adults
Traffic-related air pollution correlates with adult-onset asthma among never-smokers (Publications)
BACKGROUND: Traffic-related pollution is associated with asthma onset in children. Its effect on adult-onset asthma is poorly investigated. OBJECTIVE: We used the SAPALDIA cohort study to investigate
Reduced exposure to PM10 and attenuated age-related decline in lung function (Publications)
BACKGROUND: Air pollution has been associated with impaired health, including reduced lung function in adults. Moving to cleaner areas has been shown to attenuate adverse effects of air pollution on l
Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - results from the SAPALDIA... (Publications)
OBJECTIVE: Carotid intima media thickness (CIMT) and local stiffness are vascular biomarkers of atherosclerotic burden. We investigated the variability and reproducibility of clinically relevant struc
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (Publications)
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 seco
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland a
Re-estimated equations for 5th percentiles of lung function variables (Letter to editors) (Publications)
In 1996 we published reference equations for the 5th percentiles of lung function parameters (FVC, FEV1, PEF, FEF25, FEF50, FEF75, FEF25-75, FEV1/FVC) as a function of age and height.1 These reference
