Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs (Publications)
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or
Smoking cessation in workplace settings: quit rates and determinants in a group behaviour therapy programme (Publications)
INTRODUCTION: To capitalise on the opportunities that the smoking ban legislation in Switzerland offers for the prevention of tobacco-related diseases, a smoking cessation programme in a workplace set
Beyond immune escape: a variant surface glycoprotein causes suramin resistance in <em>Trypanosoma brucei</em> (Publications)
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by T
Physical activity and health-related quality of life among schoolchildren from disadvantaged neighbourhoods in Port Elizabeth, South Africa (Publications)
PURPOSE: The relationship between health-related quality of life (HRQoL), physical activity (PA), and cardiorespiratory fitness (CRF) among disadvantaged communities in low- and middle-income countrie
Residential air pollution and associations with wheeze and shortness of breath in adults: a combined analysis of cross-sectional data from two large... (Publications)
BACKGROUND: Research examining associations between air pollution exposure and respiratory symptoms in adults has generally been inconclusive. This may be related in part to sample size issues, which
Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine and mefloquine in <em>Schistosoma mansoni-</em>infected... (Publications)
To date there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promisin
Estimating the burden of scrub typhus: a systematic review (Publications)
BACKGROUND: Scrub typhus is a vector-borne zoonotic disease that can be life-threatening. There are no licensed vaccines, or vector control efforts in place. Despite increasing awareness in endemic re