Recherche de *.

1. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing (Publications)

   GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

   Pertinence:

   Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito

2. Human and animal schistosomiasis and fascioliasis in a mobile pastoralist setting at Lake Chad: a One Health approach (Publications)

   Human and animal schistosomiasis and fascioliasis in a mobile pastoralist setting at Lake Chad: a One Health approach

   Pertinence:

3. Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study (Publications)

   Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study

   Pertinence:

   BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studie

4. Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific (Publications)

   Total synthesis and biological investigation of (-)-artemisinin: the antimalarial activity of artemisinin is not stereospecific

   Pertinence:

   Here, we describe an efficient and diversity oriented entry to both (-)-artemisinin (1) and to its natural antipode (+)-artemisinin starting from commercially and readily available S-(+)- and R-(-)-ci

5. Cleaning at home and at work in relation to lung function decline and airway obstruction (Publications)

   Cleaning at home and at work in relation to lung function decline and airway obstruction

   Pertinence:

   RATIONALE: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional clean

6. The impact of the scale-up of malaria rapid diagnostic tests on the routine clinical diagnosis procedures for febrile illness: a series of repeated... (Publications)

   The impact of the scale-up of malaria rapid diagnostic tests on the routine clinical diagnosis procedures for febrile illness: a series of repeated cross-sectional studies in Papua New Guinea

   Pertinence:

   BACKGROUND: This paper examines the impact of the scale-up of malaria rapid diagnostic tests (RDT) on routine clinical diagnosis procedures for febrile illness in primary healthcare settings in Papua

7. Sedentary behaviour in Swiss children and adolescents: disentangling associations with the perceived and objectively measured environment (Publications)

   Sedentary behaviour in Swiss children and adolescents: disentangling associations with the perceived and objectively measured environment

   Pertinence:

   Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study

8. Quantifying human-environment interactions using videography in the context of infectious disease transmission (Publications)

   Quantifying human-environment interactions using videography in the context of infectious disease transmission

   Pertinence:

   Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments. Interaction events occur during an i

9. 2<em>H</em>-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design (Publications)

   2<em>H</em>-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design

   Pertinence:

   Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether

10. Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and <em>trypanosoma brucei... (Publications)

    Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and <em>trypanosoma brucei </em>inhibitors

    Pertinence:

    Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) like cysteine protease produced by Trypanosoma brucei ( T. b.) species and a potential drug target for the treatment of human African trypanoso