Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect (Publications)
BACKGROUND: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk (Publications)
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (> /=140 mm Hg systolic blood
Buruli ulcer disease: prospects for a vaccine (Publications)
Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD is a mutilating disease leading to se
Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides (Publications)
Although antischistosomal properties of peroxides were studied in recent years, systematic structure-activity relationships have not been conducted. We evaluated the antischistosomal potential of 64 p
Engineered synthetic virus-like particles and their use in vaccine delivery (Publications)
Engineered nanoparticles have been designed based on the self-assembling properties of synthetic coiled-coil lipopeptide building blocks. The presence of an isoleucine zipper within the lipopeptide to
Evaluation of decontamination methods and growth media for primary isolation of <em>Mycobacterium ulcerans</em> from surgical specimens (Publications)
We evaluated four decontamination methods and one nondecontamination procedure in combination with four egg-based media for the primary isolation of Mycobacterium ulcerans from tissue specimens. With
Effect of strategic gastrointestinal nematode control on growth of N'Dama cattle in Gambia (Publications)
From October 1989 to December 1994, a longitudinal study on the control of gastrointestinal nematodes was done on 1000 N'Dama cattle in 20 private herds in Gambia. Each herd was divided into two group