PCR correction strategies for malaria drug trials: updates and clarifications (Publications)
Malaria drug trials conducted in endemic areas face a major challenge in their analysis because it is difficult to establish whether parasitaemia in blood samples collected after treatment indicate dr
Going operational with health systems governance: supervision and incentives to health workers for increased quality of care in Tanzania (Publications)
Improving the quality of care is increasingly recognized as a priority of health systems in low- and middle-income countries. Given the labour-intensive nature of healthcare interventions, quality of
A new chemotype with promise against <em>Trypanosoma cruzi</em> (Publications)
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of > /=10. The initial structure-activity relationship (SAR) indicates th
Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma (Publications)
BACKGROUND: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response
Non-randomized studies using causal-modelling may give different answers than RCTs: a meta-epidemiological study (Publications)
OBJECTIVES: To evaluate how estimated treatment effects agree between non-randomized studies using causal modelling with marginal structural models (MSM-studies) and randomized trials (RCTs). STUDY DE
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducte