The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to <em>Plasmodium falciparum</em> parasite resistance (Publications)
The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here
Incidence of <em>Plasmodium falciparum</em> malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea (Publications)
BACKGROUND: Extensive malaria control measures have been implemented on Bioko Island, Equatorial Guinea over the past 16 years, reducing parasite prevalence and malaria-related morbidity and mortality
Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of... (Publications)
BACKGROUND: Automated radiologic analysis using computer-aided detection software (CAD) could facilitate chest X-ray (CXR) use in tuberculosis diagnosis. There is little to no evidence on the accuracy
Long-term exposure to air pollution and liver cancer incidence in six European cohorts (Publications)
Particulate matter air pollution and diesel engine exhaust have been classified as carcinogenic for lung cancer, yet few studies have explored associations with liver cancer. We used six European adul
Costing interventions in the field: preliminary cost estimates and lessons learned from an evaluation of community-wide mass drug administration for... (Publications)
OBJECTIVE: To present a costing study integrated within the DeWorm3 multi-country field trial of community-wide mass drug administration (cMDA) for elimination of soil-transmitted helminths. DESIGN: T
Reaching absent and refusing individuals during home-based HIV testing through self-testing-at what cost? (Publications)
Introduction: In the HOSENG trial (NCT03598686), the secondary distribution of oral self-tests for persons absent or refusing to test during a home-based HIV testing campaign in rural Lesotho resulted
Estimating intervention effectiveness in trials of malaria interventions with contamination (Publications)
Background In cluster randomized trials (CRTs) or stepped wedge cluster randomized trials (SWCRTs) of malaria interventions, mosquito movement leads to contamination between trial arms unless buffer z
The additive effect of interpregnancy interval and maternal body mass index on pregnancy induced hypertension in the U.S (Publications)
OBJECTIVES: The incidence of pregnancy induced hypertension (PIH), one of the most frequent causes of maternal and neonatal morbidity, has increased significantly in the U.S. in last two decades. Howe