Recherche de open.

1. Efficacy and safety of artesunate plus amodiaquine and artemether plus lumefantrine in the treatment of uncomplicated <em>Plasmodium falciparum</em>... (Publications)

   Efficacy and safety of artesunate plus amodiaquine and artemether plus lumefantrine in the treatment of uncomplicated <em>Plasmodium falciparum</em> malaria in the Democratic Republic of Congo: an open-label randomized trial

   Pertinence:

2. Managing research and surveillance projects in real-time using a novel open-source eManagement tool designed for low-resourced countries (Publications)

   Managing research and surveillance projects in real-time using a novel open-source eManagement tool designed for low-resourced countries

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3. OpenMalaria, a simulator of malaria transmission and morbidity, and the use of BOINC for high-throughput computing (Publications)

   OpenMalaria, a simulator of malaria transmission and morbidity, and the use of BOINC for high-throughput computing

   Pertinence:

4. Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases (Publications)

   Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases

   Pertinence:

   monitoring and evaluation. What is currently missing is a georeferenced global database for NTDs providing open-access to the available survey data that is constantly updated and can be utilized by researchers [...] including a host of other NTDs, e.g. soil-transmitted helminthiasis and leishmaniasis. CONCLUSIONS: An open-access, spatially explicit NTD database offers unique opportunities for disease risk modeling, targeting

5. Single-center outcome analysis of 1,161 patients with St. Jude medical and ATS open pivot mechanical heart valves (Publications)

   Single-center outcome analysis of 1,161 patients with St. Jude medical and ATS open pivot mechanical heart valves

   Pertinence:

   BACKGROUND AND AIM OF THE STUDY: The clinical performance of mechanical heart valves and valve-related complications are important safety endpoints in patients after heart valve replacement. In this r

6. Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a... (Publications)

   Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

   Pertinence:

   report extended follow-up to 19 months, including efficacy results. METHODS: We did a randomised, open-label, phase 2 trial of safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with

7. Eleven-year single-center experience with the ATS Open Pivot Bileaflet heart valve (Publications)

   Eleven-year single-center experience with the ATS Open Pivot Bileaflet heart valve

   Pertinence:

   BACKGROUND: The ATS Open Pivot Heart Valve was first introduced in 1992 and has been implanted routinely at our institution since 1993. Valve selection was based on surgeon preference. The objective of [...] 11-year experience demonstrates low rates of adverse events and valve-related complications with the ATS Open Pivot heart valve

8. Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against <em>Schistosoma haematobium</em>: a randomized, exploratory,... (Publications)

   Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against <em>Schistosoma haematobium</em>: a randomized, exploratory, open-label trial

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   BACKGROUND: Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The an

9. Tribendimidine and albendazole for treating soil-transmitted helminths, <em>Strongyloides stercoralis</em> and <em>Taenia</em> spp.: open-label... (Publications)

   Tribendimidine and albendazole for treating soil-transmitted helminths, <em>Strongyloides stercoralis</em> and <em>Taenia</em> spp.: open-label randomized trial

   Pertinence:

   point to activity against cestodes and Strongyloides ratti. METHODOLOGY/PRINCIPAL FINDINGS: In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine

10. Orally active antischistosomal early leads identified from the open access malaria box (Publications)

    Orally active antischistosomal early leads identified from the open access malaria box

    Pertinence:

    BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline t