Publications

Nickel B, Krebs C, Ruf M.T, Anuar N.S, Noordin R. An evaluation of a lateral flow rapid diagnostic test for Strongyloides stercoralis infection. Acta Trop. 2024;258:107336. DOI: 10.1016/j.actatropica.2024.107336

Steinsiepe V.K, Ruf M.T, Rossi M, Fricker-Feer C, Kolenc D, Buser B.S, Concu M, Neumayr A, Schneider U.C. Human Taenia martis neurocysticercosis, Switzerland. Emerg Infect Dis. 2023;29(12):2569-2572. DOI: 10.3201/eid2912.230697

Dettwiler I, Troell K, Robinson G, Chalmers R.M, Basso W, Renteria-Solis Z.M, Daugschies A, Mühlethaler K, Dale M, Basapathi Raghavendra J, Ruf M.T, Poppert S, Meylan M, Olias P. TIDE analysis of Cryptosporidium infections by gp60 typing reveals obscured mixed infections. J Infect Dis. 2022;225(4):686-695. DOI: 10.1093/infdis/jiab417

Dreyfus A, Ruf M.T, Goris M, Poppert S, Mayer-Scholl A, Loosli N, Bier N.S, Paris D.H, Tshokey T, Stenos J, Rajaonarimirana E, Concha G, Orozco J, Colorado J, Aristizábal A, Dib J.C, Kann S. Comparison of the serion IgM ELISA and Microscopic Agglutination Test for diagnosis of Leptospira spp. infections in sera from different geographical origins and estimation of s seroprevalence in the Wiwa indigenous population from Colom. PLoS Negl Trop Dis. 2022;16(6):e0009876. DOI: 10.1371/journal.pntd.0009876

Hall B.S, Dos Santos S.J, Hsieh L.T, Manifava M, Ruf M.T, Pluschke G, Ktistakis N, Simmonds R.E. Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity. Autophagy. 2022;18(4):841-859. DOI: 10.1080/15548627.2021.1961067

Hsieh L.T, Dos Santos S.J, Hall B.S, Ogbechi J, Loglo A.D, Salguero F.J, Ruf M.T, Pluschke G, Simmonds R.E. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions. PLoS Pathog. 2022;18:e1010280. DOI: 10.1371/journal.ppat.1010280

Ruf M.T. Immunohistochemistry: a method to analyze M. ulcerans infected skin tissue. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans:, 7-15. New York, NY: Humana, 2022. (Methods in molecular biology: 2387). DOI: 10.1007/978-1-0716-1779-3_2

Van der Auwera G, Davidsson L, Buffet P, Ruf M.T, Gramiccia M, Varani S, Chicharro C, Bart A, Harms G, Chiodini P.L, Brekke H, Robert-Gangneux F, Cortes S, Verweij J.J, Scarabello A, Karlsson Söbirk S, Guéry R, van Henten S, Di Muccio T, Carra E, van Thiel P, Vandeputte M, Gaspari V, Blum J, LeishMan Surveillance Network. Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis. Euro Surveill. 2022;27(4):1560-7917. (in addition to authors above). DOI: 10.2807/1560-7917.ES.2022.27.4.2002028

Dreyfus A, Ruf M.T, Mayer-Scholl A, Zitzl T, Loosli N, Bier N.S, Hiereth S, Ulrich S, Poppert S, Straubinger R.K, Stenos J, Tshokey T. Exposure to Leptospira spp. and associated risk factors in the human, cattle and dog populations in Bhutan. Pathogens. 2021;10(3):308. DOI: 10.3390/pathogens10030308

Itani O, Monsel G, Mrad M, Ruf T, Paris L, Caumes E. Gnathostomiasis in a traveller returning from Madagascar. J Travel Med. 2021;28(6):taab039. DOI: 10.1093/jtm/taab039

Nasri J, Cajacob L, Wirz E, Ruf M.T, Blum J, Muhleisen B, Navarini A.A, Maul L.V. Pre-ulcerative leishmaniasis mimicking chilblains in a returning traveler from Southern Europe. J Eur Acad Dermatol Venereol. 2021;35(8):e503-e505. DOI: 10.1111/jdv.17233

Please H.R, Vas Nunes J.H, Patel R, Pluschke G, Tholley M, Ruf M.T, Bolton W, Scott J.A, Grobusch M.P, Bolkan H.A, Brown J.M, Jayne D.G. Chronic wounds in Sierra Leone: searching for Buruli ulcer, a NTD caused by Mycobacterium ulcerans, at Masanga Hospital. PLoS Negl Trop Dis. 2021;15(10):e0009862. DOI: 10.1371/journal.pntd.0009862

Roure S, Fernández-Rivas G, Ruf M.T, Grau-López L, Guarro L, Matas L, Nickel B, Valerio L. A cluster of travelers with headache and a hidden travel companion, Angiostrongylus cantonensis: a diagnostic challenge. Travel Med Infect Dis. 2021;44:102187. DOI: 10.1016/j.tmaid.2021.102187

Chankongsin S, Wampfler R, Ruf M.T, Odermatt P, Marti H, Nickel B, Keoluangkhot V, Neumayr A. Strongyloides stercoralis prevalence and diagnostics in Vientiane, Lao People's Democratic Republic. Infect Dis Poverty. 2020;9:133. DOI: 10.1186/s40249-020-00750-y

Kaltenbach Hans-Michael, Rudolf Fabian, Linnik Janina, Deichmann Julia, Ruf Therese, Altamura Raffaele, Kapetanovic Edo, Mason Derek, Wagner Bastian, Goetz Thomas, Mundorff Lukas, Stoll-Rudin Karin, Krebs Christina, Renz Tanja, Hochueli Thomas, Haymoz Sergio, Hosch Markus, Périat Nadine, Richert Michèle, Sesia Sergio, Paris Daniel, Quinto Carlos Beat, Probst-Hensch Nicole M, Niederhauser Christoph, Reddy Sai, Nickel Beatrice, Savic Miodrag. Initial characterisation of commercially available ELISA tests and the immune response of the clinically correlated SARS-CoV-2 biobank “SERO-BL-COVID-19” collected during the pandemic onset in Switzerland. medRxiv. 2020:2020.07.05.20145888. DOI: 10.1101/2020.07.05.20145888

Légeret C, Rüttimann C, Furlano R.I, Ruf T, Poppert S, Fankhauser H, Köhler H. Blastocystis in Swiss children: a practical approach. Eur J Pediatr. 2020;179(6):979-984. DOI: 10.1007/s00431-020-03599-3

Muigg V, Al Toutonji A, Ruf M.T, Sydow V, Wampfler R, Poppert S, Neumayr A. Mysterious nematodes in gastric mucosal biopsies - a diagnostic challenge. Travel Med Infect Dis. 2020;36:101781. DOI: 10.1016/j.tmaid.2020.101781

Thomas S.S, Kalia N.P, Ruf M.T, Pluschke G, Pethe K. Toward a single-dose cure for Buruli ulcer. Antimicrob Agents Chemother. 2020;64(9):e00727-20. DOI: 10.1128/AAC.00727-20

Warryn L, Dangy J.P, Gersbach P, Gehringer M, Schäfer A, Ruf M.T, Ruggli N, Altmann K.H, Pluschke G. Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2020;14(6):e0008357. DOI: 10.1371/journal.pntd.0008357

Bolz M, Ruf M.T. Buruli ulcer in animals and experimental infection models. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 159-182. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_9

Brummaier T, Bertschy S, Arn K, Treumann T, Ruf M.T, Nickel B, Paris D.H, Neumayr A, Blum J. A blind passenger: a rare case of documented seroconversion in an Angiostrongylus cantonensis induced eosinophilic meningitis in a traveler visiting friends and relatives. Trop Dis Travel Med Vaccines. 2019;5:6. DOI: 10.1186/s40794-019-0084-x

Guenin-Macé L, Ruf M.T, Pluschke G, Demangel C. Mycolactone: more than just a cytotoxin. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 117-134. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_7

Muigg V, Ruf M.T, Schwarzkopf S, Huang S, Denisjuk N, Stürmann A, Ritzler M, Wampfler R, Poppert S, Neumayr A. Case report: human subcutaneous sparganosis in a Thai migrant. Am J Trop Med Hyg. 2019;101(5):1170-1173. DOI: 10.4269/ajtmh.19-0456

Sah R, Gupta N, Chatterji P, Krishan S, Aggarwal M, Sood N, Neupane S, Sah S, Sah R, Poppert S, Ruf M.T, Nickel B, Neumayr A. Case report: paragonimiasis presenting with pericardial tamponade. Am J Trop Med Hyg. 2019;101(1):62-64. DOI: 10.4269/ajtmh.19-0018

Scherr N, Bieri R, Thomas S.S, Chauffour A, Kalia N.P, Schneide P, Ruf M.T, Lamelas A, Manimekalai M.S.S, Grüber G, Ishii N, Suzuki K, Tanner M, Moraski G.C, Miller M.J, Witschel M, Jarlier V, Pluschke G, Pethe K. Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer. Nat Commun. 2018;9:5370. DOI: 10.1038/s41467-018-07804-8

Bieri R, Scherr N, Ruf M.T, Dangy J.P, Gersbach P, Gehringer M, Altmann K.H, Pluschke G. The macrolide toxin mycolactone promotes bim-dependent apoptosis in Buruli ulcer through inhibition of mTOR. ACS Chem Biol. 2017;12(5):1297-1307. DOI: 10.1021/acschembio.7b00053

Panic G, Ruf M.T, Keiser J. Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine and mefloquine in Schistosoma mansoni-infected mice. Antimicrob Agents Chemother. 2017;61(12):e01142-17. DOI: 10.1128/AAC.01142-17

Ruf M.T, Andreoli A, Vujic G, Itin P, Pluschke G, Schmid P. Exudate collection using wound sponges - an easy, non-invasive and reliable method to explore protease activities in ulcers. Wound Repair Regen. 2017;25(2):320-326. DOI: 10.1111/wrr.12517

Ruf M.T, Steffen C, Bolz M, Schmid P, Pluschke G. Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria. Virulence. 2017;8(8):1918-1926. DOI: 10.1080/21505594.2017.1370530

Bieri R, Bolz M, Ruf M.T, Pluschke G. Interferon-gamma is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice. PLoS Negl Trop Dis. 2016;10(2):e0004450. DOI: 10.1371/journal.pntd.0004450

Bolz M, Ruggli N, Borel N, Pluschke G, Ruf M.T. Local cellular immune responses and pathogenesis of Buruli ulcer lesions in the experimental Mycobacterium ulcerans pig infection model. PLoS Negl Trop Dis. 2016;10(4):e0004678. DOI: 10.1371/journal.pntd.0004678

Ruf M.T, Bolz M, Vogel M, Bayi P.F, Bratschi M.W, Sopho G.E, Yeboah-Manu D, Um Boock A, Junghanss T, Pluschke G. Spatial distribution of Mycobacterium ulcerans in Buruli ulcer lesions: implications for laboratory diagnosis. PLoS Negl Trop Dis. 2016;10(6):e0004767. DOI: 10.1371/journal.pntd.0004767

Vogel M, Bayi P.F, Ruf M.T, Bratschi M.W, Bolz M, Um Boock A, Zwahlen M, Pluschke G, Junghanss T. Local heat application for the treatment of Buruli ulcer: results of a phase II open label single center non comparative clinical trial. Clin Infect Dis. 2016;62(3):342-350. DOI: 10.1093/cid/civ883

Andreoli A, Bratschi M.W, Bolz M, Minyem J.C, Grize L, Wantong F.G, Kerber S, Tabah E.N, Ruf M.T, Mou F, Noumen D, Boock A.U, Pluschke G. Epidemiology of Buruli ulcer in the Mape Dam region of Cameroon: a longitudinal study. Trop Med Int Health, 2015;20(Suppl. 1):245. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Andreoli A, Ruf M.T, Itin P, Pluschke G, Schmid P. Phosphorylation of the ribosomal protein S6, a marker of mTOR pathway activation, is strongly increased in hypertrophic scars and keloids [Research letter]. Br J Dermatol. 2015;172(5):1415-1417. DOI: 10.1111/bjd.13523

Bolz M, Ruggli N, Ruf M.T, Ricklin M.E, Zimmer G, Pluschke G. Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. Trop Med Int Health, 2015;20(Suppl. 1):240. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Dreyer A, Röltgen K, Dangy J.P, Ruf M.T, Scherr N, Bolz M, Tobias N.J, Moes C, Vettiger A, Stinear T.P, Pluschke G. Identification of the Mycobacterium ulcerans protein MUL_3720 as a promising target for the development of a diagnostic test for Buruli ulcer. PLoS Negl Trop Dis. 2015;9(2):e0003477. DOI: 10.1371/journal.pntd.0003477

Ogbechi J, Ruf M.T, Hall B.S, Bodman-Smith K, Vogel M, Wu H.L, Stainer A, Esmon C.T, Ahnstrom J, Pluschke G, Simmonds R.E. Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions. PLoS Pathog. 2015;11(7):e1005011. DOI: 10.1371/journal.ppat.1005011

Röltgen K, Dreyer A, Dangy J.P, Scherr N, Ruf M.T, Kerber S, Ndung'u J.M, Pluschke G. On the way to point-of-care diagnostics for Buruli ulcer: an antigen capture approach. Trop Med Int Health, 2015;20(Suppl. 1):55

Ruf M.T, Andreoli A, Sopoh G.E, Schmid P, Pluschke G. Immunohistochemical monitoring of wound healing in Buruli ulcer patients treated with RIF/STR. Trop Med Int Health, 2015;20(Suppl. 1):241. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Tuffour J, Owusu-Mireku E, Ruf M.T, Aboagye S, Kpeli G, Akuoku V, Pereko J, Paintsil A, Bonney K, Ampofo W, Pluschke G, Yeboah-Manu D. Challenges associated with management of Buruli ulcer/human immunodeficiency virus coinfection in a treatment center in Ghana: a case series study. Am J Trop Med Hyg. 2015;93(2):216-223. DOI: 10.4269/ajtmh.14-0571

Andreoli A, Ruf M.T, Sopoh G.E, Schmid P, Pluschke G. Immunohistochemical monitoring of wound healing in antibiotic treated Buruli ulcer patients. PLoS Negl Trop Dis. 2014;8(4):e2809. DOI: 10.1371/journal.pntd.0002809

Bolz M, Ruggli N, Ruf M.T, Ricklin M.E, Zimmer G, Pluschke G. Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. PLoS Negl Trop Dis. 2014;8(7):e2968. DOI: 10.1371/journal.pntd.0002968

Bratschi M.W, Bolz M, Grize L, Kerber S, Minyem J.C, Um Boock A, Yeboah-Manu D, Ruf M.T, Pluschke G. Primary cultivation: factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical specimens. BMC Infect Dis. 2014;14:636. DOI: 10.1186/s12879-014-0636-7

Bratschi M.W, Ruf M.T, Andreoli A, Minyem J.C, Kerber S, Wantong F.G, Pritchard J, Chakwera V, Beuret C, Wittwer M, Noumen D, Schürch N, Um Book A, Pluschke G. Mycobacterium ulcerans persistence at a village water source of Buruli ulcer patients. PLoS Negl Trop Dis. 2014;8(3):e2756. DOI: 10.1371/journal.pntd.0002756

Ruf M.T, Andreoli A, Itin P, Pluschke G, Schmid P. Ribosomal protein S6 is hyper-activated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis. Br J Dermatol. 2014;171(6):1533-1536. DOI: 10.1111/bjd.13248

Vettiger A, Scherr N, Ruf M.T, Röltgen K, Pluschke G. Localization of mycobacterial antigens by immunofluorescence staining of agarose embedded cells. Mycobact Dis. 2014;4(3):1000150. DOI: 10.4172/2161-1068.1000150

Bratschi M.W, Bolz M, Minyem J.C, Grize L, Wantong F.G, Kerber S, Njih Tabah E, Ruf M.T, Mou F, Noumen D, Um Boock A, Pluschke G. Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the mape basin of cameroon. PLoS Negl Trop Dis. 2013;7(6):e2252. DOI: 10.1371/journal.pntd.0002252

Guenin-Macé L, Veyron-Churlet R, Thoulouze M, Romet-Lemonne G, Hong H, Leadlay P.F, Danckaert A, Ruf M.T, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier M.F, Demangel C. Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest. 2013;123(4):1501-1512. DOI: 10.1172/JCI66576

Pluschke G, Ruf M.T. Pathogenesis and treatment of Buruli ulcer: a histopathological perspective. Am J Trop Med Hyg, 2013;89(5 Suppl.):358

Röltgen K, Dreyer A, Dangy J.P, Bratschi M.W, Ruf M.T, Kerber S, Yeboah-Manu D, Pluschke G. Point-of-care diagnosis for the emerging skin disease, Buruli ulcer: an antigen capture approach. Am J Trop Med Hyg, 2013;89(5 Suppl.):357

Yeboah-Manu D, Kpeli G.S, Ruf M.T, Asan-Ampah K, Quenin-Fosu K, Owusu-Mireku E, Akuoko V, Paintsil A, Lamptey I, Anku B, Kwakye-Maclean C, Newman M, Pluschke G. Assessment of bacterial burden of Buruli ulcer (BU) lesions: a call for clear guidelines on wound care module for BU case management. Am J Trop Med Hyg, 2013;89(5 Suppl.):28-29

Yeboah-Manu D, Kpeli G.S, Ruf M.T, Asan-Ampah K, Quenin-Fosu K, Owusu-Mireku E, Paintsil A, Anku B, Kwakye-Maclean C, Newman M, Pluschke G. Secondary bacterial infections of Buruli ulcer lesions before and after chemotherapy with Streptomycin and Rifampicin. PLoS Negl Trop Dis. 2013;7(5):e2191. DOI: 10.1371/journal.pntd.0002191

Ruf M.T, Schütte D, Chauffour A, Jarlier V, Ji B, Pluschke G. Chemotherapy associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse model. Antimicrob Agents Chemother. 2012;56(2):687-696. DOI: 10.1128/AAC.05543-11

Ruf M.T, Chauty A, Adeye A, Ardant M.F, Koussemou H, Johnson R.C, Pluschke G. Secondary Buruli ulcer skin lesions emerging several months after completion of chemotherapy: paradoxical reaction or evidence for immune protection?. PLoS Negl Trop Dis. 2011;5(8):e1252. DOI: 10.1371/journal.pntd.0001252

Ruf M.T, Sopoh G.E, Brun L.V, Dossou A.D, Barogui Y.T, Johnson R.C, Pluschke G. Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy: a role for surgical removal of necrotic tissue?. PLoS Negl Trop Dis. 2011;5(9):e1334. DOI: 10.1371/journal.pntd.0001334

Ruf Marie-Thérèse. Mycobacterium ulcerans disease and treatment: a histopathological perspective. Basel: Univ. Basel, 2011. Doctoral Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-005707433

Käser M, Ruf M.T, Hauser J, Pluschke G. Optimized DNA preparation from mycobacteria. Cold Spring Harb Protoc. 2010;2010(4):pdb.prot5408. DOI: 10.1101/pdb.prot5408

Pidot S.J, Porter J.L, Marsollier L, Chauty A, Migot-Nabias F, Badaut C, Benard A, Ruf M.T, Seemann T, Johnson P.D, Davies J.K, Jenkin G.A, Pluschke G, Stinear T.P. Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics. PLoS Negl Trop Dis. 2010;4(11):e872. DOI: 10.1371/journal.pntd.0000872

Röltgen K, Qi W, Ruf M.T, Mensah-Quainoo E, Pidot S.J, Seemann T, Stinear T.P, Käser M, Yeboah-Manu D, Pluschke G. Single nucleotide polymorphism typing of Mycobacterium ulcerans reveals focal transmission of Buruli ulcer in a highly endemic region of Ghana. PLoS Negl Trop Dis. 2010;4(7):e751. DOI: 10.1371/journal.pntd.0000751

Käser M, Ruf M.T, Hauser J, Marsollier L, Pluschke G. Optimized method for preparation of DNA from pathogenic and environmental mycobacteria. Appl Environ Microbiol. 2009;75(2):414-418

Huber C.A, Ruf M.T, Pluschke G, Käser M. Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion. Clin Vaccine Immunol. 2008;15(4):598-606. DOI: 10.1128/CVI.00472-07