Publications

Awor P, Coppée R, Khim N, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Balikagala B, Odongo-Aginya E.I, Anywar D.A, Mita T, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda. Antimicrob Agents Chemother. 2024;68(8):e0165923. DOI: 10.1128/aac.01659-23

Brunner N.C, Karim A, Athieno P, Kimera J, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T.T, Lambiris M, Ogwal A, Nakiganda J, Mpanga F, Kagwire F, Amutuhaire M, Burri C, Lengeler C, Awor P, Hetzel M.W. Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda. PLOS Glob Public Health. 2023;3(7):e0001949. DOI: 10.1371/journal.pgph.0001949

Hetzel M.W, Awor P, Tshefu A, Omoluabi E, Burri C, Signorell A, Lambiris M.J, Visser T, Cohen J.M, Buj V, Lengeler C. Pre-referral rectal artesunate: no cure for unhealthy systems. Lancet Infect Dis. 2023;23(6):e213-e217. DOI: 10.1016/S1473-3099(22)00762-9

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Kwiatkowski M, Lambiris M.J, Visser T, Cohen J.M, Buj V, Burri C, Lengeler C. Pre-referral rectal artesunate is no "magic bullet" in weak health systems. BMC Med. 2023;21:119. DOI: 10.1186/s12916-023-02777-y

Lambiris M.J, Venga G.N, Ssempala R, Balogun V, Galactionova K, Musiitwa M, Kagwire F, Olosunde O, Emedo E, Luketa S, Sangare M, Buj V, Delvento G, Tshefu A, Okitawutshu J, Omoluabi E, Awor P, Signorell A, Hetzel M.W, Lee T.T, Brunner N.C, Cereghetti N, Visser T, Napier H.G, Burri C, Lengeler C. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints. Lancet Glob Health. 2023;11(2):e256-e264. DOI: 10.1016/S2214-109X(22)00507-1

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Okitawutshu J, Tshefu A, Kalenga J.C, Delvento G, Burri C, Hetzel M.W, Lengeler C, Signorell A. Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo. Malar J. 2023;22:308. DOI: 10.1186/s12936-023-04737-6

Signorell A, Awor P, Okitawutshu J, Tshefu A, Omoluabi E, Hetzel M.W, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T.T, Brunner N.C, Lambiris M.J, Okuma J, Cereghetti N, Buj V, Visser T, Napier H.G, Lengeler C, Burri C. Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: an operational study. PLoS Med. 2023;20(2):e1004189. DOI: 10.1371/journal.pmed.1004189

Thawer S.G, Golumbeanu M, Lazaro S, Chacky F, Munisi K, Aaron S, Molteni F, Lengeler C, Pothin E, Snow R.W, Alegana V.A. Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania. Sci Rep. 2023;13:10600. DOI: 10.1038/s41598-023-37669-x

Awor P, Kimera J, Athieno P, Tumukunde G, Okitawutshu J, Tshefu A, Omoluabi E, Signorell A, Brunner N, Kalenga J.C, Akano B, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T, Burri C, Lengeler C, Hetzel M.W. Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda. Malar J. 2022;21:322. DOI: 10.1186/s12936-022-04348-7

Awor P, Kimera J, Brunner N.C, Athieno P, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T, Amutuhaire M, Opigo J, Kaggwa F.M, Kagwire F, Nakiganda J, Burri C, Lengeler C, Hetzel M.W. Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household surveys (2018-2020). Am J Trop Med Hyg. 2022;107(4):934–938. DOI: 10.4269/ajtmh.21-1132

Brunner N.C, Omoluabi E, Awor P, Okitawutshu J, Tshefu Kitoto A, Signorell A, Akano B, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Delvento G, Lee T.T, Lambiris M.J, Ross A, Cereghetti N, Visser T, Napier H.G, Buj V, Burri C, Lengeler C, Hetzel M.W. Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda. BMJ Glob Health. 2022;7(5):e008346. DOI: 10.1136/bmjgh-2021-008346

Fink G, Mrema S, Abdulla S, Kachur P, Khatib R, Lengeler C, Masanja H, Okumu F, Schellenberg D. Mosquito net use in early childhood and survival to adulthood in Tanzania. N Engl J Med. 2022;386:428-436. DOI: 10.1056/NEJMoa2112524

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Brunner N.C, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Delvento G, Lee T.T, Lambiris M.J, Kwiatkowski M, Cereghetti N, Visser T, Napier H.G, Cohen J.M, Buj V, Burri C, Lengeler C. Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study. BMC Med. 2022;20:343. DOI: 10.1186/s12916-022-02541-8

Lengeler C, Burri C, Awor P, Athieno P, Kimera J, Tumukunde G, Angiro I, Tshefu A, Okitawutshu J, Kalenga J.-C, Omoluabi E, Akano B, Ayodeji K, Okon C, Yusuf O, Brunner N.C, Delvento G, Lee T, Lambiris M.J, Visser T, Napier H.G, Cohen J.M, Buj V, Signorell A, Hetzel Manuel W, Caramal Consortium. Community access to rectal artesunate for malaria (CARAMAL): a large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. PLoS Glob Public Health. 2022;2(9):e0000464. DOI: 10.1371/journal.pgph.0000464

Okitawutshu J, Signorell A, Kalenga J.C, Mukomena E, Delvento G, Burri C, Mwaluke F, Buj V, Sangare M, Luketa S, Brunner N, Lee T, Hetzel M, Lengeler C, Tshefu A. Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo. Malar J. 2022;21:274. DOI: 10.1186/s12936-022-04296-2

Polonsky J.A, Bhatia S, Fraser K, Hamlet A, Skarp J, Stopard I.J, Hugonnet S, Kaiser L, Lengeler C, Blanchet K, Spiegel P. Feasibility, acceptability, and effectiveness of non-pharmaceutical interventions against infectious diseases among crisis-affected populations: a scoping review. Infect Dis Poverty. 2022;11:14. DOI: 10.1186/s40249-022-00935-7

Runge M, Thawer S.G, Molteni F, Chacky F, Mkude S, Mandike R, Snow R.W, Lengeler C, Mohamed A, Pothin E. Sub-national tailoring of malaria interventions in mainland Tanzania: simulation of the impact of strata-specific intervention combinations using modelling. Malar J. 2022;21:92. DOI: 10.1186/s12936-022-04099-5

Thawer S.G, Golumbeanu M, Munisi K, Aaron S, Chacky F, Lazaro S, Mohamed A, Kisoka N, Lengeler C, Molteni F, Ross A, Snow R.W, Pothin E. The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania. Malar J. 2022;21:345. DOI: 10.1186/s12936-022-04364-7

Yin J.H, Lengeler C, Tanner M, Zhou X.N. A malaria-free China: global importance and key experience. Adv Parasitol. 2022;116:xv-xix. DOI: 10.1016/S0065-308X(22)00027-6

Arn Karoline. Christian Lengeler: Malaria breitet sich wieder aus [Radio Broadcast] [Internet]. Zürich: SRF, 2021. [Date Accessed: 21.04.2021]. Available from: https://podcasts.srf.ch/world/audio/Tagesgespraech_21-04-2021-1300.1619006356184.mp3

Awor P, Khim N, Coppée R, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Clonal expansion of artemisinin-resistant Plasmodium falciparum in Uganda is associated with substandard treatment practices. Lancet. 2021(in press). DOI: 10.2139/ssrn.3974542

Lee T.T, Omoluabi E, Ayodeji K, Yusuf O, Okon C, Brunner N.C, Delvento G, Signorell A, Lambiris M, Kwiatkowski M, Burri C, Lengeler C, Emedo E, Cheshi F, Hetzel M.W. Treatment-seeking for children with suspected severe malaria attending community health workers and primary health centres in Adamawa State, Nigeria. medRxiv. 2021(in press). DOI: 10.1101/2021.12.01.21267130

Mudji J, Yaka K, Olarewaju V, Lengeler C. Prevalence and risk factors for malaria in pregnancy in Vanga, Democratic Republic of Congo. Afr J Reprod Health. 2021;25(5):14-24. DOI: 10.29063/ajrh2021/v25i5.2

Runge M, Molteni F, Mandike R, Snow R.W, Lengeler C, Mohamed A, Pothin E. Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania. Malar J. 2020;19:101. DOI: 10.1186/s12936-020-03173-0

Runge M, Snow R.W, Molteni F, Thawer S, Mohamed A, Mandike R, Giorgi E, Macharia P.M, Smith T.A, Lengeler C, Pothin E. Simulating the council-specific impact of anti-malaria interventions: a tool to support malaria strategic planning in Tanzania. PLoS One. 2020;15(2):e0228469. DOI: 10.1371/journal.pone.0228469

Thawer S.G, Chacky F, Runge M, Reaves E, Mandike R, Lazaro S, Mkude S, Rumisha S.F, Kumalija C, Lengeler C, Mohamed A, Pothin E, Snow R.W, Molteni F. Sub-national stratification of malaria risk in mainland Tanzania: a simplified assembly of survey and routine data. Malar J. 2020;19:177. DOI: 10.1186/s12936-020-03250-4

Yukich J, Stuck L, Scates S, Wisniewski J, Chacky F, Festo C, Kabulika G, Dimoso K, Mandike R, Greer G, Serbantez N, Elisaria E, Nyoni W, Dadi D, Akim I, Lengeler C, Brown N, Koenker H. Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania. Malar J. 2020;19:158. DOI: 10.1186/s12936-020-03222-8

Brunner N.C, Chacky F, Mandike R, Mohamed A, Runge M, Thawer S.G, Ross A, Vounatsou P, Lengeler C, Molteni F, Hetzel M.W. The potential of pregnant women as a sentinel population for malaria surveillance. Malar J. 2019;18:370. DOI: 10.1186/s12936-019-2999-0

Lechthaler F, Matthys B, Lechthaler-Felber G, Likwela J.L, Mavoko H.M, Rika J.M, Mutombo M.M, Ruckstuhl L, Barczyk J, Shargie E, Prytherch H, Lengeler C. Trends in reported malaria cases and the effects of malaria control in the Democratic Republic of the Congo. PLoS One. 2019;14(7):e0219853. DOI: 10.1371/journal.pone.0219853

Renggli S, Mayumana I, Mboya D, Charles C, Mshana C, Kessy F, Glass T.R, Lengeler C, Schulze A, Aerts A, Pfeiffer C. Towards improved health service quality in Tanzania: contribution of a supportive supervision approach to increased quality of primary healthcare. BMC Health Serv Res. 2019;19:848. DOI: 10.1186/s12913-019-4648-2

Renggli S, Mayumana I, Mboya D, Charles C, Mshana C, Kessy F, Glass T.R, Pfeiffer C, Schulze A, Aerts A, Lengeler C. Towards improved health service quality in Tanzania: appropriateness of an electronic tool to assess quality of primary healthcare. BMC Health Serv Res. 2019;19:55. DOI: 10.1186/s12913-019-3908-5

Renggli S, Mayumana I, Mshana C, Mboya D, Kessy F, Tediosi F, Pfeiffer C, Aerts A, Lengeler C. Looking at the bigger picture: how the wider health financing context affects the implementation of the Tanzanian Community Health Funds. Health Policy Plan. 2019;34(1):12-23. DOI: 10.1093/heapol/czy091

Chacky F, Runge M, Rumisha S.F, Machafuko P, Chaki P, Massaga J.J, Mohamed A, Pothin E, Molteni F, Snow R.W, Lengeler C, Mandike R. Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania. Malar J. 2018;17:452. DOI: 10.1186/s12936-018-2601-1

Koenker H, Arnold F, Ba F, Cissé M, Diouf L, Eckert E, Erskine M, Florey L, Fotheringham M, Gerberg L, Lengeler C, Lynch M, Mnzava A, Nasr S, Ndiop M, Poyer S, Renshaw M, Shargie E, Taylor C, Thwing J, Van Hulle S, Ye Y, Yukich J, Kilian A. Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used?. Malar J. 2018;17:355. DOI: 10.1186/s12936-018-2505-0

Lengeler C, Hetzel M, Signorell A, Awor P, Tshefu A, Okitawutshu J, Omoluabi E, Nepomnyashchiy L, Fast J, Ramachandra S, Goldstein R, Buj V, Burri C. Introducing rectal artesunate in community settings and evaluating its impact. 7th MIM Pan African Malaria Conference. Dakar, Senegal, 2018

Maia M.F, Kliner M, Richardson M, Lengeler C, Moore S.J. Mosquito repellents for malaria prevention (Review). Cochrane Database Syst Rev. 2018(2):CD011595. DOI: 10.1002/14651858.CD011595.pub2

Pryce J, Richardson M, Lengeler C. Insecticide-treated nets for preventing malaria. Cochrane Database Syst Rev. 2018;11:CD000363. DOI: 10.1002/14651858.CD000363.pub3

Renggli S, Mayumana I, Mboya D, Charles C, Maeda J, Mshana C, Kessy F, Tediosi F, Pfeiffer C, Schulze A, Aerts A, Lengeler C. Towards improved health service quality in Tanzania: An approach to increase efficiency and effectiveness of routine supportive supervision. PLoS One. 2018;13(9):e0202735. DOI: 10.1371/journal.pone.0202735

Signorell A, Hetzel M, Awor P, Tshefu A, Okitawutshu J, Omoluabi E, Nepomnyashchiy L, Burri C, Lengeler C. CARAMAL: addressing the remaining burden of malaria deaths by optimizing the use of rectla artesunate. 7th MIM Pan African Malaria Conference. Dakar, Senegal, 2018