Publications

Awor P, Coppée R, Khim N, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Balikagala B, Odongo-Aginya E.I, Anywar D.A, Mita T, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda. Antimicrob Agents Chemother. 2024;68(8):e0165923. DOI: 10.1128/aac.01659-23

Giduthuri J.G, Timbi D, Kualawi M, Are C, Muri M, Philemon G, Hetzel M, Pomat W. Papua New Guinea malaria indicator survey 2022-2023: final report on malaria prevention, infection prevalence, and treatment-seeking. Goroka: Papua New Guinea Institute of Medical Research, 2024. DOI: 10.5281/zenodo.10630064

Holzschuh A, Lerch A, Fakih B.S, Aliy S.M, Ali M.H, Ali M.A, Bruzzese D.J, Yukich J, Hetzel M.W, Koepfli C. Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of Plasmodium falciparum: a feasibility study. PLOS Glob Public Health. 2024;4(2):e0002743. DOI: 10.1371/journal.pgph.0002743

Brunner N.C, Karim A, Athieno P, Kimera J, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T.T, Lambiris M, Ogwal A, Nakiganda J, Mpanga F, Kagwire F, Amutuhaire M, Burri C, Lengeler C, Awor P, Hetzel M.W. Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda. PLOS Glob Public Health. 2023;3(7):e0001949. DOI: 10.1371/journal.pgph.0001949

Das A.M, Hetzel M.W, Yukich J.O, Stuck L, Fakih B.S, Al-mafazy A.H, Ali A, Chitnis N. Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania. Nat Commun. 2023;14:2750. DOI: 10.1038/s41467-023-38379-8

Fakih B.S, Holzschuh A, Ross A, Stuck L, Abdul R, Al-mafazy A.H, Irema I, Mbena A, Thawer S.G, Shija S.J, Aliy S.M, Ali A, Fink G, Yukich J, Hetzel M.W. Risk of imported malaria infections in Zanzibar: a cross-sectional study. Infect Dis Poverty. 2023;12:80. DOI: 10.1186/s40249-023-01129-5

Golumbeanu M, Edi C.A.V, Hetzel M.W, Koepfli C, Nsanzabana C. Bridging the gap from molecular surveillance to programmatic decisions for malaria control and elimination. Am J Trop Med Hyg. 2023(in press). DOI: 10.4269/ajtmh.22-0749

Hetzel M.W, Awor P, Tshefu A, Omoluabi E, Burri C, Signorell A, Lambiris M.J, Visser T, Cohen J.M, Buj V, Lengeler C. Pre-referral rectal artesunate: no cure for unhealthy systems. Lancet Infect Dis. 2023;23(6):e213-e217. DOI: 10.1016/S1473-3099(22)00762-9

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Kwiatkowski M, Lambiris M.J, Visser T, Cohen J.M, Buj V, Burri C, Lengeler C. Pre-referral rectal artesunate is no "magic bullet" in weak health systems. BMC Med. 2023;21:119. DOI: 10.1186/s12916-023-02777-y

Holzschuh A, Lerch A, Gerlovina I, Fakih B.S, Al-mafazy A.H, Reaves E.J, Ali A, Abbas F, Ali M.H, Ali M.A, Hetzel M.W, Yukich J, Koepfli C. Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania. Nat Commun. 2023;14:3699. DOI: 10.1038/s41467-023-39417-1

Lambiris M.J, Venga G.N, Ssempala R, Balogun V, Galactionova K, Musiitwa M, Kagwire F, Olosunde O, Emedo E, Luketa S, Sangare M, Buj V, Delvento G, Tshefu A, Okitawutshu J, Omoluabi E, Awor P, Signorell A, Hetzel M.W, Lee T.T, Brunner N.C, Cereghetti N, Visser T, Napier H.G, Burri C, Lengeler C. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints. Lancet Glob Health. 2023;11(2):e256-e264. DOI: 10.1016/S2214-109X(22)00507-1

Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593

Okitawutshu J, Tshefu A, Kalenga J.C, Delvento G, Burri C, Hetzel M.W, Lengeler C, Signorell A. Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo. Malar J. 2023;22:308. DOI: 10.1186/s12936-023-04737-6

Signorell A, Awor P, Okitawutshu J, Tshefu A, Omoluabi E, Hetzel M.W, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T.T, Brunner N.C, Lambiris M.J, Okuma J, Cereghetti N, Buj V, Visser T, Napier H.G, Lengeler C, Burri C. Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: an operational study. PLoS Med. 2023;20(2):e1004189. DOI: 10.1371/journal.pmed.1004189

Awor P, Kimera J, Athieno P, Tumukunde G, Okitawutshu J, Tshefu A, Omoluabi E, Signorell A, Brunner N, Kalenga J.C, Akano B, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T, Burri C, Lengeler C, Hetzel M.W. Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda. Malar J. 2022;21:322. DOI: 10.1186/s12936-022-04348-7

Awor P, Kimera J, Brunner N.C, Athieno P, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T, Amutuhaire M, Opigo J, Kaggwa F.M, Kagwire F, Nakiganda J, Burri C, Lengeler C, Hetzel M.W. Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household surveys (2018-2020). Am J Trop Med Hyg. 2022;107(4):934–938. DOI: 10.4269/ajtmh.21-1132

Brunner N.C, Omoluabi E, Awor P, Okitawutshu J, Tshefu Kitoto A, Signorell A, Akano B, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Delvento G, Lee T.T, Lambiris M.J, Ross A, Cereghetti N, Visser T, Napier H.G, Buj V, Burri C, Lengeler C, Hetzel M.W. Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda. BMJ Glob Health. 2022;7(5):e008346. DOI: 10.1136/bmjgh-2021-008346

Cleary E, Hetzel M.W, Clements A.C.A. A review of malaria epidemiology and control in Papua New Guinea 1900 to 2021: progress made and future directions. Front Epidemiol. 2022;2:980795. DOI: 10.3389/fepid.2022.980795

Das A.M, Hetzel M.W, Yukich J.O, Stuck L, Fakih B.S, Al-mafazy A.H, Ali A, Chitnis N. The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility. Epidemics. 2022;41:100639. DOI: 10.1016/j.epidem.2022.100639

Giduthuri J.G, Kualawi M, Muri M, Are C, Goi P, Minn Oo M, Hetzel M.W, Pomat W. Papua New Guinea national health facility survey 2021: availability and quality of malaria case management. Goroka: Papua New Guinea Institute of Medical Research, 2022

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Brunner N.C, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Delvento G, Lee T.T, Lambiris M.J, Kwiatkowski M, Cereghetti N, Visser T, Napier H.G, Cohen J.M, Buj V, Burri C, Lengeler C. Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study. BMC Med. 2022;20:343. DOI: 10.1186/s12916-022-02541-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Walker E.D. Vector composition, abundance, biting patterns and malaria transmission intensity in Madang, Papua New Guinea: assessment after 7 years of an LLIN-based malaria control programme. Malar J. 2022;21:7. DOI: 10.1186/s12936-021-04030-4

Lengeler C, Burri C, Awor P, Athieno P, Kimera J, Tumukunde G, Angiro I, Tshefu A, Okitawutshu J, Kalenga J.-C, Omoluabi E, Akano B, Ayodeji K, Okon C, Yusuf O, Brunner N.C, Delvento G, Lee T, Lambiris M.J, Visser T, Napier H.G, Cohen J.M, Buj V, Signorell A, Hetzel Manuel W, Caramal Consortium. Community access to rectal artesunate for malaria (CARAMAL): a large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. PLoS Glob Public Health. 2022;2(9):e0000464. DOI: 10.1371/journal.pgph.0000464

Namango I.H, Marshall C, Saddler A, Ross A, Kaftan D, Tenywa F, Makungwa N, Odufuwa O.G, Ligema G, Ngonyani H, Matanila I, Bharmal J, Moore J, Moore S.J, Hetzel M.W. The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) compared to the human landing catch (HLC) for measuring Anopheles biting in rural Tanzania. Malar J. 2022;21:181. DOI: 10.1186/s12936-022-04192-9

Naung M.T, Martin E, Munro J, Mehra S, Guy A.J, Laman M, Harrison G.L.A, Tavul L, Hetzel M, Kwiatkowski D, Mueller I, Bahlo M, Barry A.E. Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens. PLoS Comput Biol. 2022;18(2):e1009801. DOI: 10.1371/journal.pcbi.1009801

Okitawutshu J, Signorell A, Kalenga J.C, Mukomena E, Delvento G, Burri C, Mwaluke F, Buj V, Sangare M, Luketa S, Brunner N, Lee T, Hetzel M, Lengeler C, Tshefu A. Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo. Malar J. 2022;21:274. DOI: 10.1186/s12936-022-04296-2

Seidahmed O, Jamea S, Kurumop S, Timbi D, Makita L, Ahmed M, Freeman T, Pomat W, Hetzel M.W. Stratification of malaria incidence in Papua New Guinea (2011–2019): contribution towards a sub-national control policy. PLoS Glob Public Health. 2022;2(11):e0000747. DOI: 10.1371/journal.pgph.0000747

Vera-Arias C.A, Holzschuh A, Oduma C.O, Badu K, Abdul-Hakim M, Yukich J, Hetzel M.W, Fakih B.S, Ali A, Ferreira M.U, Ladeia-Andrade S, Sáenz F.E, Afrane Y, Zemene E, Yewhalaw D, Kazura J.W, Yan G, Koepfli C. High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy. eLife. 2022;11:e72083. DOI: 10.7554/eLife.72083

Awor P, Khim N, Coppée R, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Clonal expansion of artemisinin-resistant Plasmodium falciparum in Uganda is associated with substandard treatment practices. Lancet. 2021(in press). DOI: 10.2139/ssrn.3974542

Brunner N.C, Awor P, Hetzel M.W. Definitions of severity in treatment seeking studies of febrile illness in children in low and middle income countries: a scoping review. Int J Public Health. 2021;66:634000. DOI: 10.3389/ijph.2021.634000

Cleary E, Hetzel M.W, Siba P, Lau C.L, Clements A.C.A. Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:269. DOI: 10.1186/s12936-021-03804-0

Cleary E, Hetzel M.W, Siba P.M, Lau C.L, Clements A.C.A. Correction to: Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:318. DOI: 10.1186/s12936-021-03838-4

Gul D, Rodríguez-Rodríguez D, Nate E, Auwan A, Salib M, Lorry L, Keven J.B, Katusele M, Rosado J, Hofmann N, Ome-Kaius M, Koepfli C, Felger I, Kazura J.W, Hetzel M.W, Mueller I, Karl S, Clements A.C.A, Fowkes F.J.I, Laman M, Robinson L.J. Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea. Sci Rep. 2021;11:16540. DOI: 10.1038/s41598-021-95959-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Foran D.R, Walker E.D. Nonrandom selection and multiple blood feeding of human hosts by Anopheles vectors: implications for malaria transmission in Papua New Guinea. Am J Trop Med Hyg. 2021;105(6):1747-1758. DOI: 10.4269/ajtmh.21-0210

Lautu-Gumal D, Razook Z, Koleala T, Nate E, McEwen S, Timbi D, Hetzel M.W, Lavu E, Tefuarani N, Makita L, Kazura J, Mueller I, Pomat W, Laman M, Robinson L.J, Barry A.E. Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018. Int J Parasitol Drugs Drug Resist. 2021;16:188-193. DOI: 10.1016/j.ijpddr.2021.06.004

Lee T.T, Omoluabi E, Ayodeji K, Yusuf O, Okon C, Brunner N.C, Delvento G, Signorell A, Lambiris M, Kwiatkowski M, Burri C, Lengeler C, Emedo E, Cheshi F, Hetzel M.W. Treatment-seeking for children with suspected severe malaria attending community health workers and primary health centres in Adamawa State, Nigeria. medRxiv. 2021(in press). DOI: 10.1101/2021.12.01.21267130

Rodríguez-Rodríguez D, Katusele M, Auwun A, Marem M, Robinson L.J, Laman M, Hetzel M.W, Pulford J. Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea. J Infect Dis. 2021;223(Suppl. 2):S171-S186. DOI: 10.1093/infdis/jiaa402

Seidahmed O.M.E, Kurumop S, Jamea-Maiasa S, Timbi D, Tandrapah A, Hetzel M, Pomat W. Papua New Guinea malaria indicator survey 2019-2020: final report on malaria prevention, infection prevalence, and treatment-seeking. Goroka: Papua New Guinea Institute of Medical Research, PNGIMR, 2021

Grossenbacher B, Holzschuh A, Hofmann N.E, Omar K.A, Stuck L, Fakih B.S, Ali A, Yukich J, Hetzel M.W, Felger I. Molecular methods for tracking residual Plasmodium falciparum transmission in a close-to-elimination setting in Zanzibar. Malar J. 2020;19:50. DOI: 10.1186/s12936-020-3127-x

Hetzel M. PNG’s health data: too much of a good thing – part two. Australia: Devpolicy Blog, 2020