Publications

Alahmad B, Khraishah H, Kamineni M, Royé D, Papatheodorou S.I, Vicedo-Cabrera A.M, Guo Y, Lavigne E, Armstrong B, Sera F, Bernstein A.S, Zanobetti A, Garshick E, Schwartz J, Bell M.L, Al-Mulla F, Koutrakis P, Gasparrini A, Multi-Country Multi-City (MCC) Collaborative Research Network. Extreme temperatures and stroke mortality: evidence from a multi-country analysis. Stroke. 2024;55(7):1847-1856. DOI: 10.1161/strokeaha.123.045751

Chen G, Guo Y, Yue X, Xu R, Yu W, Ye T, Tong S, Gasparrini A, Bell M.L, Armstrong B, Schwartz J, Jaakkola J.J.K, Lavigne E, Saldiva P.H.N, Kan H, Royé D, Urban A, Vicedo-Cabrera A.M, Tobias A, Forsberg B, Sera F, Lei Y, Abramson M.J, Li S, MCC Collaborative Research Network. All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis. Lancet Planet Health. 2024;8(7):e452-e462. DOI: 10.1016/s2542-5196(24)00117-7

Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L, Roye D, Lavigne E, Kyselý J, Urban A, Schneider A, Huber V, Madureira J, Mistry M.N, Cvijanovic I, MCC Collaborative Research Network, Gasparrini A, Vicedo-Cabrera A.M. Impact of population aging on future temperature-related mortality at different global warming levels. Nat Commun. 2024;15:1796. DOI: 10.1038/s41467-024-45901-z

Domingo N.G.G, Fiore A.M, Lamarque J.F, Kinney P.L, Jiang L, Gasparrini A, Breitner S, Lavigne E, Madureira J, Masselot P, das Neves Pereira da Silva S, Sheng Ng C.F, Kyselý J, Guo Y, Tong S, Kan H, Urban A, Orru H, Maasikmets M, Pascal M, Katsouyanni K, Samoli E, Scortichini M, Stafoggia M, Hashizume M, Alahmad B, Diaz M.H, la Cruz Valencia C, Scovronick N, Garland R.M, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli M.S, Guo Y.L, Pan S.C, Colistro V, Bell M, Zanobetti A, Schwartz J, Schneider A, Vicedo-Cabrera A.M, Chen K. Ozone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement. One Earth. 2024;7(2):325-335. DOI: 10.1016/j.oneear.2024.01.001

Gasparrini A, Vicedo-Cabrera A.M, Tobias A, MCC Collaborative Research Network. The Multi-Country Multi-City Collaborative Research Network: an international research consortium investigating environment, climate, and health. Environ Epidemiol. 2024;8(5):e339. DOI: 10.1097/ee9.0000000000000339

Guo Q, Mistry M.N, Zhou X, Zhao G, Kino K, Wen B, Yoshimura K, Satoh Y, Cvijanovic I, Kim Y, Ng C.F.S, Vicedo-Cabrera A.M, Armstrong B, Urban A, Katsouyanni K, Masselot P, Tong S, Sera F, Huber V, Bell M.L, Kyselý J, Gasparrini A, Hashizume M, Oki T, MCC Collaborative Research Network. Regional variation in the role of humidity on city-level heat-related mortality. PNAS Nexus. 2024;3(8):pgae290. DOI: 10.1093/pnasnexus/pgae290

He C, Breitner-Busch S, Huber V, Chen K, Zhang S, Gasparrini A, Bell M, Kan H, Royé D, Armstrong B, Schwartz J, Sera F, Vicedo-Cabrera A.M, Honda Y, Jaakkola J.J.K, Ryti N, Kyselý J, Guo Y, Tong S, de'Donato F, Michelozzi P, De Sousa Zanotti Stagliorio Coelho M, Saldiva P.H.N, Lavigne E, Orru H, Indermitte E, Pascal M, Goodman P, Zeka A, Kim Y, Diaz M.H, Arellano E.E.F, Overcenco A, Klompmaker J, Rao S, Palomares A.D, Carrasco G, Seposo X, das Neves Pereira da Silva S, Madureira J, Holobaca I.H, Scovronick N, Acquaotta F, Kim H, Lee W, Hashizume M, Tobias A, Íñiguez C, Forsberg B, Ragettli M.S, Guo Y.L, Pan S.C, Osorio S, Li S, Zanobetti A, Dang T.N, Van Dung D, Schneider A. Rainfall events and daily mortality across 645 global locations: two stage time series analysis. BMJ. 2024;387:e080944. DOI: 10.1136/bmj-2024-080944

Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A.M, Hales S, Johnson A, Li S, Guo Y, MCC Collaborative Research Network. Global and regional cardiovascular mortality attributable to nonoptimal temperatures over time. J Am Coll Cardiol. 2024;83(23):2276-2287. DOI: 10.1016/j.jacc.2024.03.425

Lüthi S, Fairless C, Fischer E.M, Scovronick N, Armstrong B, De Sousa Zanotti Stagliorio Coelho M, Guo Y.L, Guo Y, Honda Y, Huber V, Kyselý J, Lavigne E, Royé D, Ryti N, Silva S, Urban A, Gasparrini A, Bresch D.N, Vicedo-Cabrera A.M, Multi-Country Multi-City (MCC) Collaborative Research Network. Author Correction: Rapid increase in the risk of heat-related mortality. Nat Commun. 2024;15:8110. DOI: 10.1038/s41467-023-44107-z

Madaniyazi L, Armstrong B, Tobias A, Mistry M.N, Bell M.L, Urban A, Kyselý J, Ryti N, Cvijanovic I, Ng C.F.S, Roye D, Vicedo-Cabrera A.M, Tong S, Lavigne E, Íñiguez C, da Silva Sdnp, Madureira J, Jaakkola J.J.K, Sera F, Honda Y, Gasparrini A, Hashizume M, MCC Collaborative Research Network. Seasonality of mortality under climate change: a multicountry projection study. Lancet Planet Health. 2024;8(2):e86-e94. DOI: 10.1016/s2542-5196(23)00269-3

Orlov A, De Hertog S.J, Havermann F, Guo S, Manola I, Lejeune Q, Schleussner C.F, Thiery W, Pongratz J, Humpenöder F, Popp A, Aunan K, Armstrong B, Royé D, Cvijanovic I, Lavigne E, Achilleos S, Bell M, Masselot P, Sera F, Vicedo-Cabrera A.M, Gasparrini A, Mistry M.N, Multi-Country Multi-City (MCC) Collaborative Research Network. Impacts of land-use and land-cover changes on temperature-related mortality. Environ Epidemiol. 2024;8(6):e337. DOI: 10.1097/ee9.0000000000000337

Ragettli M, Luyten A, Röösli M. Monitoring hitzebedingte Todesfälle Sommer 2023: Impact-Indikator «Hitzebedingte Todesfälle». Bern: Bundesamt für Umwelt (BAFU) und Bundesamt für Gesundheit (BAG), 2024

Ragettli M.S, Flückiger B, Vienneau D, Domingo-Irigoyen S, Koschenz M, Röösli M. Vulnerability to heat-related mortality and the effect of prevention measures: a time-stratified case-crossover study in Switzerland. Swiss Med Wkly. 2024;154(10):3410. DOI: 10.57187/s.3418

Ragettli M.S, Schulte F, Röösli M. Hitzekompetenz der Bevölkerung 50+ in der Schweiz: Wissen, Betroffenheit, Handeln im Sommer 2023. Allschwil: Swiss TPH, 2024

Schulte F, Röösli M, Ragettli M.S. Risk, attributable fraction and attributable number of cause-specific heat-related emergency hospital admissions in Switzerland. Int J Public Health. 2024;69:1607349. DOI: 10.3389/ijph.2024.1607349

Schwarz M, Peters A, Stafoggia M, de'Donato F, Sera F, Bell M.L, Guo Y, Honda Y, Huber V, Jaakkola J.J.K, Urban A, Vicedo-Cabrera A.M, Masselot P, Lavigne E, Achilleos S, Kyselý J, Samoli E, Hashizume M, Fook Sheng Ng C, das Neves Pereira da Silva S, Madureira J, Garland R.M, Tobias A, Armstrong B, Schwartz J, Gasparrini A, Schneider A, Breitner S, MMC Collaborative Research Network. Temporal variations in the short-term effects of ambient air pollution on cardiovascular and respiratory mortality: a pooled analysis of 380 urban areas over a 22-year period. Lancet Planet Health. 2024;8(9):e657-e665. DOI: 10.1016/s2542-5196(24)00168-2

Scovronick N, Sera F, Vu B, Vicedo-Cabrera A.M, Roye D, Tobias A, Seposo X, Forsberg B, Guo Y, Li S, Honda Y, Abrutzky R, de Sousa Zanotti Stagliorio Coelho M, Nascimento Saldiva P.H, Lavigne E, Kan H, Osorio S, Kyselý J, Urban A, Orru H, Indermitte E, Jaakkola J.J, Ryti N, Pascal M, Katsouyanni K, Mayvaneh F, Entezari A, Goodman P, Zeka A, Michelozzi P, de'Donato F, Hashizume M, Alahmad B, Zanobetti A, Schwartz J, Hurtado Diaz M, De La Cruz Valencia C, Rao S, Madureira J, Acquaotta F, Kim H, Lee W, Iniguez C, Ragettli M.S, Guo Y.L, Dang T.N, Dung D.V, Armstrong B, Gasparrini A. Temperature-mortality associations by age and cause: a multi-country multi-city study. Environ Epidemiol. 2024;8(5):e336. DOI: 10.1097/ee9.0000000000000336

Wen B, Wu Y, Guo Y, Gasparrini A, Tong S, Overcenco A, Urban A, Schneider A, Entezari A, Vicedo-Cabrera A.M, Zanobetti A, Analitis A, Zeka A, Tobias A, Nunes B, Alahmad B, Armstrong B, Forsberg B, Pan S.-C, Íñiguez C, Ameling C, De la Cruz Valencia C, Åström C, Houthuijs D, Van Dung D, Royé D, Indermitte E, Lavigne E, Mayvaneh F, Acquaotta F, de'Donato F, Rao S, Sera F, Carrasco-Escobar G, Kan H, Orru H, Kim H, Holobaca I.-H, Kyselý J, Madureira J, Schwartz J, Jaakkola J.J.K, Katsouyanni K, Hurtado Diaz M, Ragettli M.S, Hashizume M, Pascal M, de Sousa Zanotti Stagliorio Coélho M, Valdés Ortega N, Ryti N, Scovronick N, Michelozzi P, Matus Correa P, Goodman P, Saldiva P.H.N, Raz R, Abrutzky R, Osorio S, Dang T.N, Colistro V, Huber V, Lee W, Seposo X, Honda Y, Kim Y, Guo Y.L, Bell M.L, Li S. Comparison for the effects of different components of temperature variability on mortality: a multi-country time-series study. Environ Int. 2024;187:108712. DOI: 10.1016/j.envint.2024.108712

Wicki B, Flückiger B, Vienneau D, de Hoogh K, Röösli M, Ragettli M.S. Socio-environmental modifiers of heat-related mortality in eight Swiss cities: a case time series analysis. Environ Res. 2024;246:118116. DOI: 10.1016/j.envres.2024.118116

Wu Y, Wen B, Gasparrini A, Armstrong B, Sera F, Lavigne E, Li S, Guo Y, MCC Collaborative Research Network. Temperature frequency and mortality: assessing adaptation to local temperature. Environ Int. 2024;187:108691. DOI: 10.1016/j.envint.2024.108691

Yang D, Hashizume M, Tobías A, Honda Y, Roye D, Oh J, Dang T.N, Kim Y, Abrutzky R, Guo Y, Tong S, De Sousa Zanotti Stagliorio Coelho M, Saldiva P.H.N, Lavigne E, Correa P.M, Ortega N.V, Osorio S, Kyselý J, Urban A, Orru H, Indermitte E, Jaakkola J, Ryti N, Pascal M, Huber V, Schneider A, Katsouyanni K, Analitis A, Entezari A, Mayvaneh F, Goodman P, Zeka A, Michelozzi P, de’Donato F, Alahmad B, Diaz M.H, Valencia C.D.L.C, Overcenco A, Houthuijs D, Ameling C, Rao S, Nunes B, Madureira J, Holo-Bâc I.H, Scovronick N, Acquaotta F, Kim H, Lee W, Íñiguez C, Forsberg B, Vicedo-Cabrera A.M, Ragettli M.S, Guo Y.L.L, Pan S.C, Li S, Sera F, Zanobetti A, Schwartz J, Armstrong B, Gasparrini A, Chung Y. Temporal change in minimum mortality temperature under changing climate: a multicountry multicommunity observational study spanning 1986–2015. Environ Epidemiol. 2024;8(5):e334. DOI: 10.1097/EE9.0000000000000334

Alahmad B, Khraishah H, Royé D, Vicedo-Cabrera A.M, Guo Y, Papatheodorou S.I, Achilleos S, Acquaotta F, Armstrong B, Bell M.L, Pan SC, De Sousa Zanotti Staglioro Coelho M, Colistro V, Dang T.N, Dung D.V, De' Donato F.K, Entezari A, Guo YL, Hashizume M, Honda Y, Indermitte E, Íñiguez C, Jaakkola J.J.K, Kim H, Lavigne E, Lee W, Li S, Madureira J, Mayvaneh F, Orru H, Overcenco A.V, Ragettli M.S, Ryti N.R.I, Saldiva P.H.N, Scovronick N, Seposo X, Sera F, Silva S.P, Stafoggia M, Tobias A, Garshick E, Bernstein A.S, Zanobetti A, Schwartz J.D, Gasparrini A, Koutrakis P. Associations between extreme temperatures and cardiovascular cause-specific mortality: results from 27 countries. Circulation. 2023;147(1):35-46. DOI: 10.1161/CIRCULATIONAHA.122.061832

Buteau S, Yankoty L.I, Letellier N, Benmarhnia T, Gamache P, Plante C, Goudreau S, Blais C, Perron S, Fournier M, Ragettli M.S, Smargiassi A. Associations between environmental noise and myocardial infarction and stroke: investigating the potential mediating effects of hypertension. Environ Res. 2023;231(Pt 1):116092. DOI: 10.1016/j.envres.2023.116092

Castro A, Kappeler R, Kienzler S, Kutlar Joss M, Laeremans M, Plass D, Ragettli M, Röösli M, Scutaru A.M, Valtanen K, Van de Vel K, Wauters N. Environmental health risks to children and adolescents: an umbrella review on indoor and outdoor air pollution: European Topic Centre on Human Health and the Environment, 2023

Kelly S.L, Shattock A.J, Ragettli M.S, Vienneau D, Vicedo-Cabrera A.M, de Hoogh K. The air and viruses we breathe: assessing the effect the PM2.5 air pollutant has on the burden of COVID-19. Atmosphere. 2023;14(5):887. DOI: 10.3390/atmos14050887

Lüthi S, Fairless C, Fischer E.M, Scovronick N, Ben Armstrong, De Sousa Zanotti Stagliorio Coelho M, Guo Y.L, Guo Y, Honda Y, Huber V, Kyselý J, Lavigne E, Royé D, Ryti N, Silva S, Urban A, Gasparrini A, Bresch D.N, Vicedo-Cabrera A.M. Rapid increase in the risk of heat-related mortality. Nat Commun. 2023;14:4894. DOI: 10.1038/s41467-023-40599-x

Masselot P, Mistry M, Vanoli J, Schneider R, Iungman T, Garcia-Leon D, Ciscar J.C, Feyen L, Orru H, Urban A, Breitner S, Huber V, Schneider A, Samoli E, Stafoggia M, de'Donato F, Rao S, Armstrong B, Nieuwenhuijsen M, Vicedo-Cabrera A.M, Gasparrini A, MCC Collaborative Research Network. Excess mortality attributed to heat and cold: a health impact assessment study in 854 cities in Europe. Lancet Planet Health. 2023;7(4):e271-e281. DOI: 10.1016/S2542-5196(23)00023-2

Ragettli M.S, Saucy A, Flückiger B, Vienneau D, de Hoogh K, Vicedo Cabrera A.M, Schindler C, Röösli M. Explorative assessment of the temperature–mortality association to support health-based heat-warning thresholds: a national case-crossover study in Switzerland. Int J Environ Res Public Health. 2023;20(6):4958. DOI: 10.3390/ijerph20064958

Ragettli M.S, Schulte F, Röösli M, Rieser R. Monitoring der hitzebedingten Todesfälle in der Schweiz. Schweiz Ärzteztg. 2023;104(43):30-33. DOI: 10.4414/saez.2023.1265825731

Ragettli M.S, Schulte F, Röösli M. Monitoring hitzebedingte Todesfälle 2000 bis 2022: Impact-Indikator "Hitzebedingte Todesfälle" Synthesebericht Juli 2023. Bern: Bundesamt für Umwelt (BAFU), 2023

Rai M, Stafoggia M, de'Donato F, Scortichini M, Zafeiratou S, Vazquez Fernandez L, Zhang S, Katsouyanni K, Samoli E, Rao S, Lavigne E, Guo Y, Kan H, Osorio S, Kyselý J, Urban A, Orru H, Maasikmets M, Jaakkola J.J.K, Ryti N, Pascal M, Hashizume M, Fook Sheng Ng C, Alahmad B, Hurtado Diaz M, de la Cruz Valencia C, Nunes B, Madureira J, Scovronick N, Garland R.M, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Vicedo-Cabrera A.M, Ragettli M.S, Leon Guo Y.L, Pan S.-C, Li S, Gasparrini A, Sera F, Masselot P, Schwartz J, Zanobetti A, Bell M.L, Schneider A, Breitner S. Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries. Environ Int. 2023;174:107825. DOI: 10.1016/j.envint.2023.107825

Stafoggia M, Michelozzi P, Schneider A, Armstrong B, Scortichini M, Rai M, Achilleos S, Alahmad B, Analitis A, Åström C, Bell M.L, Calleja N, Krage Carlsen H, Carrasco G, Paul Cauchi J, De Sousa Zanotti Stagliorio Coelho M, Correa P.M, Diaz M.H, Entezari A, Forsberg B, Garland R.M, Leon Guo Y, Guo Y, Hashizume M, Holobaca I.H, Íñiguez C, Jaakkola J.J.K, Kan H, Katsouyanni K, Kim H, Kyselý J, Lavigne E, Lee W, Li S, Maasikmets M, Madureira J, Mayvaneh F, Fook Sheng Ng C, Nunes B, Orru H, V, Osorio S, Palomares A.D.L, Pan S.C, Pascal M, Ragettli M.S, Rao S, Raz R, Roye D, Ryti N, Hn Saldiva P, Samoli E, Schwartz J, Scovronick N, Sera F, Tobias A, Tong S, Dlc Valencia C, Maria Vicedo-Cabrera A, Urban A, Gasparrini A, Breitner S, De' Donato F.K. Joint effect of heat and air pollution on mortality in 620 cities of 36 countries. Environ Int. 2023;181:108258. DOI: 10.1016/j.envint.2023.108258

Vicedo-Cabrera A.M, de Schrijver E, Schumacher D.L, Ragettli M.S, Fischer E.M, Seneviratne S.I. The footprint of human-induced climate change on heat-related deaths in the summer of 2022 in Switzerland. Environ Res Lett. 2023;18(7):074037. DOI: 10.1088/1748-9326/ace0d0

Choi H.M, Lee W, Heo S, Urban A, Entezari A, Vicedo-Cabrera A, Zanobetti A, Analitis A, Gasparrini A, Tobias A, Armstrong B, Forsberg B, Íñiguez C, Åström C, Roye D, Indermitte E, Lavigne E, Mayvaneh F, Acquaotta F, Sera F, Orru H, Kim H, Kyselý J, Madureira J, Schwartz J, Jaakkola J.J.K, Katsouyanni K, Hurtado Diaz M, Ragettli M.S, Pascal M, Ryti M, Scovronick N, Osorio N, Tong S, Seposo X, Guo Y.-L.L, Guo Y, Bell M.L. Effect modification of greenness on the association between heat and mortality: a multi-city multi-country study. eBioMedicine. 2022;84:104251. DOI: 10.2139/ssrn.4064658

Choi H.M, Lee W, Roye D, Heo S, Urban A, Entezari A, Vicedo-Cabrera A.M, Zanobetti A, Gasparrini A, Analitis A, Tobias A, Armstrong B, Forsberg B, Iniguez C, Astrom C, Sheng Ng C.F, Indermitte E, Lavigne E, Mayvaneh F, Acquaotta F, Sera F, Orru H, Kim H, Kyselý J, Madueira J, Schwartz J, Jaakkola J.J.K, Katsouyanni K, Diaz M.H, Ragettli M.S, Hashizume M, Pascal M, Ryti N, Scovronick N, Osorio S, Tong S, Seposo X, Honda Y, Kim Y, Guo YL, Guo Y, Bell M.L. Corrigendum to "Effect modification of greenness on the association between heat and mortality: a multi-city multi-country study". EBioMedicine. 2022;87:104396. DOI: 10.1016/j.ebiom.2022.104396

de Schrijver E, Bundo M, Ragettli M.S, Sera F, Gasparrini A, Franco O.H, Vicedo-Cabrera A.M. Nationwide analysis of the heat- and cold-related mortality trends in Switzerland between 1969 and 2017: the role of population aging. Environ Health Perspect. 2022;130(3):37001. DOI: 10.1289/EHP9835

Flückiger B, Kloog I, Ragettli M.S, Eeftens M, Röösli M, de Hoogh K. Modelling daily air temperature at a fine spatial resolution dealing with challenging meteorological phenomena and topography in Switzerland. Int J Climatol. 2022;42(12):6413-6428. DOI: 10.1002/joc.7597

Liu C, Cai J, Chen R, Sera F, Guo Y, Tong S, Li S, Lavigne E, Correa P.M, Ortega N.V, Orru H, Maasikmets M, Jaakkola J.J.K, Ryti N, Breitner S, Schneider A, Katsouyanni K, Samoli E, Hashizume M, Honda Y, Ng C.F.S, Diaz M.H, Valencia C.C, Rao S, Palomares A.D, Silva S.P.D, Madureira J, Holobâc I.H, Fratianni S, Scovronick N, Garland R.M, Tobias A, Íñiguez C, Forsberg B, Åström C, Vicedo-Cabrera A.M, Ragettli M.S, Guo Y.L, Pan S.C, Milojevic A, Bell M.L, Zanobetti A, Schwartz J, Gasparrini A, Kan H. Coarse particulate air pollution and daily mortality: a global study in 205 cities. Am J Respir Crit Care Med. 2022;206(8):999-1007. DOI: 10.1164/rccm.202111-2657OC

Masselot P, Sera F, Schneider R, Kan H, Lavigne E, Stafoggia M, Tobias A, Chen H, Burnett R.T, Schwartz J, Zanobetti A, Bell M.L, Chen B.Y, Leon Guo Y.L, Ragettli M.S, Vicedo-Cabrera A.M, Astrom C, Forsberg B, Íñiguez C, Garland R.M, Scovronick N, Madureira J, Nunes B, De la Cruz Valencia C, Hurtado Diaz M, Honda Y, Hashizume M, Fook Cheng Ng C, Samoli E, Katsouyanni K, Schneider A, Breitner S, Ryti N.R.I, Jaakkola J.J.K, Maasikmets M, Orru H, Guo Y, Valdés Ortega N, Matus Correa P, Tong S, Gasparrini A. Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study. Epidemiology. 2022;33(2):167-175. DOI: 10.1097/EDE.0000000000001455

Mistry M.N, Schneider R, Masselot P, Roye D, Armstrong B, Kysely J, Orru H, Sera F, Tong S, Lavigne E, Urban A, Madureira J, Garcia-Leon D, Ibarreta D, Ciscar J.C, Feyen L, de Schrijver E, de Sousa Zanotti Stagliorio Coelho M, Pascal M, Tobias A, Multi-Country Multi-City (MCC) Collaborative Research Network, Guo Y, Vicedo-Cabrera A.M, Gasparrini A. Comparison of weather station and climate reanalysis data for modelling temperature-related mortality. Sci Rep. 2022;12:5178. (MCC). DOI: 10.1038/s41598-022-09049-4