Publications

Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino G.I, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, Calenbergh S.V, Hirsch A.K.H, Hahne H. Studying target-engagement of anti-infectives by solvent-induced protein precipitation and quantitative mass spectrometry. ACS Infect Dis. 2024;10(12):4087-4102. DOI: 10.1021/acsinfecdis.4c00417

Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A.K.H, Mäser P, Rottmann M, Hahne H. Integral solvent-induced protein precipitation for target-engagement studies in Plasmodium Falciparum. ACS Infect Dis. 2024;10(12):4073-4086. DOI: 10.1021/acsinfecdis.4c00418

Bravo P.I. When evolution meets drug: discovery in Plasmodium falciparum.. Basel: Univ. Basel, 2024. Doctoral Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-ep96798

Diamanti E, Steinbach A.M, de Carvalho L.P, Ropponen H.K, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, Fischer M, Hamed M.M, Bach N.C, Rottmann M, Held J, Witschel M, Sieber S.A, Hirsch A.K.H. Targeting the Plasmodium falciparum IspE enzyme. ACS Omega. 2024;9:44465-44473. DOI: 10.1021/acsomega.4c06038

Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A.M, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed M.M, Diamanti E, Hirsch A.K.H. Targeting Plasmodium falciparum IspD in the methyl-d-erythritol phosphate pathway: urea-based compounds with nanomolar potency on target and low-micromolar whole-cell activity. J Med Chem. 2024;67(19):17070-17086. DOI: 10.1021/acs.jmedchem.4c00212

Diamanti E, Hamed M.M, Lacour A, Bravo P, Illarionov B, Fischer M, Rottmann M, Witschel M, Hirsch A.K.H. Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class. ChemMedChem. 2022;17(5):e202100679. DOI: 10.1002/cmdc.202100679