Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors,
Common variants in Mendelian kidney disease genes and their association with renal function (Publications)
Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common sing
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA
Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland (Publications)
Given the shrinking spatial contrasts in outdoor air pollution in Switzerland and the trends toward tightly insulated buildings, the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in
Early detection of subjects at risk for vascular remodelling - results from the Swiss population-based study SAPALDIA (Publications)
QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal associati
Intermittency ratio: a metric reflecting short-term temporal variations of transportation noise exposure (Publications)
Most environmental epidemiology studies model health effects of noise by regressing on acoustic exposure metrics that are based on the concept of average energetic dose over longer time periods (i.e.
Sleep fragmentation and sleep-disordered breathing in individuals living close to main roads: results from a population-based study (Publications)
BACKGROUND: Nighttime traffic noise is associated with sleep disturbances, but sleep fragmentation and sleep-disordered breathing (SDB) have not been demonstrated in individuals living near busy roads