Significant geographical differences in prevalence of mutations associated with <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> drug... (Publications)
BACKGROUND: Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level. National malaria programmes r
Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of <em>Schistosoma... (Publications)
BACKGROUND: Human urogenital schistosomiasis caused by Schistosoma haematobium is widely distributed across Africa and is increasingly targeted for control and regional elimination. The development of
Development of a bead-based Luminex assay using lipopolysaccharide specific monoclonal antibodies to detect biological threats from <em>Brucella... (Publications)
BACKGROUND: Brucella, a Gram-negative bacterium, is classified as a potential bioterrorism agent mainly due to the low dose needed to cause infection and the ability to transmit the bacteria via aeros
DNA methylation assessed by SMRT sequencing is linked to mutations in <em>Neisseria meningitidis</em> isolates (Publications)
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To present, proposed virulence genotypes are also detected in isolates from asymptomatic carriers, indicating
The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)
BACKGROUND: In the Tanzanian city of Dar es Salaam, high coverage of long-lasting insecticidal nets (LLINs), larvicide application (LA) and mosquito-proofed housing, was complemented with improved acc
Negligible risk of inducing resistance in <em>Mycobacterium tuberculosis</em> with single-dose rifampicin as post-exposure prophylaxis for leprosy (Publications)
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among
Design of trials for interrupting the transmission of endemic pathogens (Publications)
BACKGROUND: Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs). Pathogen elimination is th