Acetylation polymorphism and prevalence of colorectal adenomas (Publications)
Polymorphic N-acetyltransferase (NAT2), an enzyme present in the colon, may effect incidence of colon cancer. Individuals with NAT2 fast acetylator genotypes may have higher colon cancer risks due to
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African... (Publications)
We report the discovery of novel boron-containing molecules, exemplified by N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl-2-trifluoromethylbenzam ide (AN3520) and 4-Fluoro-N-(1-hydroxy-1,3-dihydr
Bis(oxyphenylene)benzimidazoles: a novel class of anti-<em>Plasmodium falciparum</em> agents (Publications)
A small library of 26 2,2'-[alkane-alpha,omega-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhode
Traffic, susceptibility, and childhood asthma (Publications)
Results from studies of traffic and childhood asthma have been inconsistent, but there has been little systematic evaluation of susceptible subgroups. In this study, we examined the relationship of lo
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently availabl
Understanding home-based neonatal care practice in rural southern Tanzania (Publications)
In order to understand home-based neonatal care practices in rural Tanzania, with the aim of providing a basis for the development of strategies for improving neonatal survival,we conducted a qualitat
Prediction of live body weight using length and girth measurements for pigs in rural western Kenya (Publications)
Objectives: To develop and validate a pig weight-estimation method using body length and girth measurements. Methods: In a random sample of 288 smallholder pig farms in Western Kenya, pigs were weighe
Operational strategies to achieve and maintain malaria elimination (Publications)
Present elimination strategies are based on recommendations derived during the Global Malaria Eradication Program of the 1960s. However, many countries considering elimination nowadays have high intri