In vivo investigations of selected diamidine compounds against <em>Trypanosoma evansi</em> using a mouse model (Publications)
Surra is an animal pathogenic protozoan infection, caused by Trypanosoma evansi, that develops into a fatal wasting disease. Control measures rely on diagnosis and treatment. However, with the continu
<em>myo</em>-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in <em>Trypanosoma brucei</em> (Publications)
myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose
A "one health" surveillance and control of brucellosis in developing countries: moving away from improvisation (Publications)
Although a "One Health" approach has been successfully implemented for emerging infectious zoonotic diseases with pandemic potential, we still lack a conceptual framework to address enzootic diseases
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines (Publications)
In an effort to address potential cardiotoxicity liabilities identified with earlier frontrunner compounds, a number of new 3,5-diaryl-2-aminopyridine derivatives were synthesized. Several compounds e
Habitat-based larval interventions: a new perspective for malaria control (Publications)
Interest in environmental management of mosquito larval habitats has been rekindled due to deterioration of malaria in tropical Africa. Environmental management programs were typically implemented as
Gender and socio-cultural determinants of delay to diagnosis of TB in Bangladesh, India and Malawi (Publications)
SETTING: Tuberculosis (TB) control programmes in Bangladesh, India and Malawi. OBJECTIVE: To compare the interval from symptom onset to diagnosis of TB for men and women, and to assess socio-cultural