The epidemiology of multiple <em>Plasmodium falcpiarum</em> infections. 11. Premunition in <em>Plasmodium falciparum </em>infection: insights from the... (Publications)
Epidemiological studies of multiple clone infections by Plasmodium falciparum in highly endemic areas have demonstrated age dependence in both the multiplicity of infection and the relationships betwe
Inhaled glucocorticoids during pregnancy and offspring pediatric diseases: a national cohort study (Publications)
RATIONALE: Glucocorticoid inhalation is the preferred asthma treatment during pregnancy. Previous studies on its safety focused on obstetric outcomes and offspring malformations. OBJECTIVE: To determi
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential (Publications)
A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library. T
Geschlechtsunterschiede in Gesundheit und Gesundheitsverhalten (Publications)
The higher life expectancy of women is contrasting with the higher female morbidity known from health interview surveys and statistics on use of health services. In the Swiss Health Survey SOMIPOPS, w
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature. This led to the identification of cynaropicrin (1) fr
Tegumental changes in adult <em>Schistosoma mansoni</em> harboured in mice treated with praziquantel enantiomers (Publications)
Praziquantel administered to the host causes damage to the tegument of Schistosoma mansoni. In this study, the effects of racemic praziquantel (Pra) and its enantiomers, levo-praziquantel (L-Pra) and
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL) (Publications)
Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania