Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix... (Publications)
Existing small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. To dev
Signifikant kürzere Anästhesiezeit bei lumbaler Wirbelsäulenchirurgie: prozessanalytischer Vergleich von Spinalanästhesie und Intubationsnarkose (Publications)
INTRODUCTION: Most surgery of the lumbar spine is performed with the patient under general anesthesia (GA); however, qualitative benefits of spinal anesthesia (SA) have been reported. The goal of this
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in
Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-a antagonists (Publications)
Patients under immunosuppressive therapy with tumor necrosis factor alpha (TNF-?) antagonists are vulnerable to various opportunistic infections including leishmaniasis. We present a case series of 8
Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. I
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives (Publications)
4,4''-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . T
Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of... (Publications)
Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which