Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort (Publications)
Background Understanding the prognostic meaning of early stages of chronic obstructive pulmonary disease (COPD) in the general population is relevant for discussions about underdiagnosis. To date, COP
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function (Publications)
In conducting genome-wide association studies (GWAS), analytic approaches leveraging biologic information may further understanding of the pathophysiology of clinical traits. To discover novel associa
Multiple loci associated with indices of renal function and chronic kidney disease (Publications)
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS
Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort (Publications)
BackgroundAlthough women with severe non-allergic asthma may represent a substantial proportion of adults with asthma in clinical practice, gender differences in the incidence of allergic and non-alle
Serum bilirubin is associated with lung function in a Swiss general population sample (Publications)
Bilirubin is a strong antioxidant. Increased serum levels were associated with respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the SAPALDIA cohort
Spatial variation of PM elemental compositon between and within 20 European study areas - results of the ESCAPE project (Publications)
An increasing number of epidemiological studies suggest that adverse health effects of air pollution may be related to particulate matter (PM) composition, particularly trace metals. However, we lack
Air pollution and diabetes association: modification by type 2 diabetes genetic risk score (Publications)
Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single varian
Land use regression models for ultrafine particles in six European areas (Publications)
Long-term ultrafine particle (UFP) exposure estimates at a fine spatial scale are needed for epidemiological studies. Land use regression (LUR) models were developed and evaluated for six European are
Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE) (Publications)
BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: