Long-term exposure to traffic-related PM10 and decreased heart rate variability: is the association restricted to subjects taking ACE inhibitors? (Publications)
BACKGROUND: Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES: We investigated whether long-te
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction... (Publications)
Background: Both air pollution and genetic variation have been shown to affect lung function. Their interaction has not been studied on a genome-wide scale to date. Objectives: We aimed to identify, i
Genome-wide association and functional follow-up reveals new loci for kidney function (Publications)
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and s
Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study (Publications)
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete re
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies (Publications)
BACKGROUND: Epigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disea
Infectious diseases are associated with carotid intima media thickness in adolescence (Publications)
OBJECTIVE: Inflammatory risk factors in childhood, e.g. obesity, impact on carotid artery intima media thickness (CIMT), an early indicator of atherosclerosis. Little is known on potential infectious