Adult onset asthma and interaction between genes and active tobacco smoking: the GABRIEL consortium (Publications)
BACKGROUND: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify nove
Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies (Publications)
BACKGROUND: The biological mechanisms by which cleaning products and disinfectants - an emerging risk factor - affect respiratory health remain incompletely evaluated. Studying genes by environment in
Associations of novel and traditional vascular biomarkers of arterial stiffness: results of the SAPALDIA 3 cohort study (Publications)
BACKGROUND AND OBJECTIVES: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional v
A large-scale, consortium-based genomewide association study of asthma (Publications)
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subt
Development of land use regression models for particle composition in twenty study areas in Europe (Publications)
Land Use Regression (LUR) models have been used to describe and model spatial variability of annual mean concentrations of traffic related pollutants such as nitrogen dioxide (NO2), nitrogen oxides (N
Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project (Publications)
ABSTRACT Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of
Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population (Publications)
Background: Because of changing world demographics, the elderly population is steadily increasing. Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objec
Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of var
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function (Publications)
Genome-wide association studies have identified > 50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analy