Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity (Publications)
New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl
Effect of residential relocation on environmental exposures in European cohorts: an exposome-wide approach (Publications)
Residential relocation is increasingly used as a natural experiment in epidemiological studies to assess the health impact of changes in environmental exposures. Since the likelihood of relocation can
Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries (Publications)
Background Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives We investigated the
ePOCT+ and the medAL-<em>suite</em>: development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients... (Publications)
Electronic clinical decision support algorithms (CDSAs) have been developed to address high childhood mortality and inappropriate antibiotic prescription by helping clinicians adhere to guidelines. Pr
Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic... (Publications)
BACKGROUND: For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antima
<em>In vitro</em> and <em>in vivo</em> antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids (Publications)
Praziquantel, the only drug in clinical use for the treatment and control of schistosomiasis, is inactive against developing infections. Ozonides are synthetic peroxide derivatives inspired by the nat
Effective coverage in health systems: evolution of a concept (Publications)
The manner in which high-impact, life-saving health interventions reach populations in need is a critical dimension of health system performance. Intervention coverage has been a standard metric for s
Measures adopted by indigent mothers in Kilifi County to tackle maternal health challenges during the COVID-19 pandemic: a qualitative study (Publications)
Many sub-Saharan African countries have experienced various challenges that threaten the quality of health services offered to the population. The COVID-19 pandemic disrupted access to healthcare serv
Cost analysis for “The Magic Glasses Philippines” health education package to prevent intestinal worm infections among Filipino schoolchildren (Publications)
Background: Soil-transmitted helminth (STH) infections are a significant public health problem affecting over 900 million people globally. Health education has been shown to complement mass drug admin