Development and adaptation of tensile strength by bones in the extremities in response to physical training exemplified by the tibia (Publications)
Results from an in vivo assessment of the bending stiffness of human tibiae with a new method demonstrate that bone mineral measurements are not a suitable predictor to evaluate changes of mechanical
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas' disease. Diaryl s
Relationship between <em>Mycobacterium tuberculosis</em> genotype and the clinical phenotype of pulmonary and meningeal tuberculosis (Publications)
We used large sequence polymorphisms to determine the genotypes of 397 isolates of Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults with pulmonary (n = 235) or
Marine natural products from the Turkish sponge <em>Agelas oroides</em> that inhibit the enoyl reductases from <em>Plasmodium falciparum</em>,<em>... (Publications)
The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzym
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies (Publications)
Primin (=2-methoxy-6-pentylcyclohexa-2,5-diene-1,4-dione), a natural benzoquinone synthesized in our laboratory, was investigated for its in vitro antiprotozoal, antimycobacterial, and cytotoxic poten
Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of <em>Scrophularia cryptophila</em> (Publications)
Resin glycosides are secondary metabolites exclusive to the convolvulaceous plants. In this study, crypthophilic acids A-C (1-3), the first resin glycosides occurring in another family (Scrophulariace