Quinolone amides as anti-trypanosomal lead compounds with in vivo activity (Publications)
Human African Trypanosomiasis (HAT) is a major tropical disease with few available drugs for treatment driving the need for novel active compounds. Recently, morpholino-substituted benzyl amides of th
Drug resistance mutations after the first 12 months on antiretroviral therapy and determinants of virologic failure in Rwanda (Publications)
OBJECTIVE: To evaluate HIV drug resistance (HIVDR) and determinants of virological failure in a large cohort of patients receiving first-line tenofovir-based antiretroviral (ART) regimens. METHODS: A
Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
Malaria is an infectious disease that needs to be addressed using innovative approaches to counteract spread of drug resistance and to establish or optimize vaccination strategies. With our approach,
Reliability of functional connectivity of EEG applying microstates-segmented versus classical calculation of phase lag index (Publications)
BACKGROUND: Connectivity analysis characterizes normal and altered brain function, e.g. using the phase lag index (PLI), which is based on phase relations. However, reliability of PLI over time is lim
Microbial contamination along the main open wastewater and storm water channel of Hanoi, Vietnam, and potential health risks for urban farmers (Publications)
The use of wastewater in agriculture and aquaculture has a long tradition throughout Asia. For example, in Hanoi, it creates important livelihood opportunities for > 500,000 farmers in peri-urban comm
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
OBJECTIVES: We evaluated the ability of the Xpert(R) MTB/RIF assay to detect Mycobacterium tuberculosis in whole blood of children with tuberculosis in tuberculosis endemic settings with high rates of
Operational performance and analysis of two rabies vaccination campaigns in N'Djamena, Chad (Publications)
Transmission of rabies from animals to people continues despite availability of good vaccines for both human and animal use. The only effective strategy to achieve elimination of dog rabies and the re
Profile: the rusinga health and demographic surveillance system, western Kenya (Publications)
The health and demographic surveillance system on Rusinga Island, Western Kenya, was initiated in 2012 to facilitate a malaria intervention trial: the SolarMal project. The project aims to eliminate m