Dual strategy to design new agents targeting <em>Schistosoma mansoni</em>: advancing phenotypic and <em>Sm</em>CB1 inhibitors for improved efficacy (Publications)
In this study, we have identified and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm Schistosoma mansoni and its target protease S. man
Urinalysis as a noninvasive health screening procedure in Falconidae (Publications)
Clinical signs of renal disorders in animals, including raptors, are not specific. Furthermore, serum or plasma biochemical parameters change only when 70% of kidney function is lost. In this study, r
Outbreaks of infectious keratoconjunctivitis in alpine chamois and ibex in Switzerland between 2001 and 2003 (Publications)
Five outbreaks of infectious keratoconjunctivitis (IKC) affecting alpine chamois and ibex in the western and central Swiss Alps were recorded in 2001 to 2003. Mycoplasma conjunctivae was identified fr
Operationalizing a community-based One Health surveillance and response in Adadle district of Ethiopia (Publications)
Surveillance of human and animal health is often carried out separately worldwide, which leads to the under-reporting of zoonotic and emerging diseases. Early cross-information between wildlife, domes
Regulation of sexual commitment in malaria parasites - a complex affair (Publications)
Malaria blood stage parasites commit to either one of two distinct cellular fates while developing within erythrocytes of their mammalian host: they either undergo another round of asexual replication
Global estimates on the number of people blind or visually impaired by glaucoma: a meta-analysis from 2000 to 2020 (Publications)
OBJECTIVES: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by glaucoma and their proportion of the total number of vision-impaired individuals. MET
Long-term exposure to transportation noise and diabetes mellitus mortality: a national cohort study and updated meta-analysis (Publications)
BACKGROUND: Long-term exposure to transportation noise is related to cardio-metabolic diseases, with more recent evidence also showing associations with diabetes mellitus (DM) incidence. This study ai
Accelerating progress towards the 2030 neglected tropical diseases targets: How can quantitative modeling support programmatic decisions? (Publications)
Over the past decade, considerable progress has been made in the control, elimination, and eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD programs have recently ex
Effects of performance-based financing on availability, quality, and use of family planning services in the Democratic Republic of Congo: an impact... (Publications)
Access to high-quality family planning services remains limited in many low- and middle-income countries, resulting in a high burden of unintended pregnancies and adverse health outcomes. We used data
Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of <em>Brasenia... (Publications)
Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal re