Mapping of genotype-phenotype diversity amongst clinical isolates of <em>Mycobacterium tuberculosis</em> by sequence-based transcriptional profiling (Publications)
Genome sequencing has identified an extensive repertoire of single nucleotide polymorphisms among clinical isolates of Mycobacterium tuberculosis, but the extent to which these differences influence p
Neglected tropical diseases: diagnosis, clinical management, treatment and control (Publications)
Branded in 2005, "neglected tropical diseases" have gained traction in terms of advocacy, interest for research, enhanced funding and political will for their control and eventual elimination. Startin
Ecohealth approach to urban waste management: exposure to environmental pollutants and health risks in Yamoussoukro, Côte d'Ivoire (Publications)
Poor waste management is a key driver of ill-health in urban settlements of developing countries. The current study aimed at assessing environmental and human health risks related to urban waste manag
Tobacco-related cancer mortality: projections for different geographical regions in Switzerland (Publications)
PRINCIPLES: Switzerland is divided into 26 cantons of variable population size and cultural characteristics. Although a federal law to protect against passive smoking and a national tobacco control pr
Can action research strengthen district health management and improve health workforce performance? A research protocol (Publications)
INTRODUCTION: The single biggest barrier for countries in sub-Saharan Africa (SSA) to scale up the necessary health services for addressing the three health-related Millennium Development Goals and ac
Bromopyrrole alkaloids as lead compounds against protozoan parasites (Publications)
In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking
Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of <em>Trypanosoma brucei</em> (Publications)
Eukaryotic elongation factor 1A (eEF1A) is the only protein modified by ethanolamine phosphoglycerol (EPG). In mammals and plants, EPG is attached to conserved glutamate residues located in eEF1A doma
Discovery and evaluation of thiazinoquinones as anti-protozoal agents (Publications)
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 muM)