Ecological drivers of <em>Mansonella perstans</em> infection in Uganda and patterns of co-endemicity with lymphatic filariasis and malaria (Publications)
BACKGROUND: Mansonella perstans is a widespread, but relatively unknown human filarial parasite transmitted by Culicoides biting midges. Although it is found in many parts of sub-Saharan Africa, only
Low prevalence of <em>Plasmodium</em> and absence of malaria transmission in Conakry, Guinea: prospects for elimination (Publications)
to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors [...] using the VecTest malaria panel assay and an enzyme-linked immunosorbent assay. A systematic research of Ministry of Health statistical yearbooks was performed to determine malaria prevalence in children [...] infection in Anopheles gambiae s.l. in the city of Conakry, Guinea, and...
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified [...] in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two [...] domain. This paper reports for the first time on 236 screens that have been...
Imported falciparum malaria in Europe: sentinel surveillance data from the European network on surveillance of imported infectious diseases (Publications)
Malaria continues to have a high morbidity rate associated among European travelers. Thorough recording of epidemiological and clinical aspects of imported malaria has been helpful in the detection of [...] to cover approximately 10% of all patients with malaria seen in Europe. Reports of 1659 immigrants and European patients with Plasmodium falciparum malaria were analyzed for epidemiological information and [...] to our understanding of the epidemiological and clinical findings regarding...
Effect of irrigation and large dams on the burden of malaria on a global and regional scale (Publications)
12.1% of the global malaria burden is concentrated. Whether an individual water project triggers an increase in malaria transmission depends on the contextual determinants of malaria, including the epi [...] conclude that in unstable malaria endemic areas, integrated malaria control measures, coupled with sound water management, are mandatory to mitigate the current burden of malaria in locations near irrigation [...] dynamics of malaria, but analyses of these environmental risk factors are...
Malaria elimination: moving forward with spatial decision support systems (Publications)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response in [...] mapping and geographical reconnaissance (GR) has traditionally played an important role in supporting malaria control and eradication, its full potential as an applied health systems tool has not yet been fully [...] spatial decision support system (SDSS) framework for supporting the...
Exploring the contributions of bed nets, cattle, insecticides and excitorepellency to malaria control: a deterministic model of mosquito host-seeking... (Publications)
Domestic and personal protection measures against malaria exposure either divert host-seeking vectors to other hosts or kill those attempting to feed. Here, we explicitly model mosquito host-seeking processes [...] technology and distribution systems for insecticide-treated nets improve, massive reductions in malaria transmission could be realised