First clinical trial of purified, irradiated malaria sporozoites in humans (Publications)
Evaluation of: Epstein JE, Tewari K, Lyke KE et al. Live attenuated malaria vaccine designed to protect through hepatic CD8 T cell immunity. Science 334(6055), 475-480 (2011). Purified, irradiated, me [...] route in humans are warranted to fully explore the potential of purified, attenuated sporozoites for malaria vaccine development
Multiplex real-time PCR for the diagnosis of malaria: correlation with microscopy (Publications)
Abstract Malaria is generally diagnosed by microscopy and rapid antigen testing. Molecular methods become more widely used. In the present study, the contribution of a quantitative multiplex malaria PCR was
Participatory mapping of target areas to enable operational larval source management to suppress malaria vector mosquitoes in Dar es Salaam, Tanzania (Publications)
Half of the population of Africa will soon live in towns and cities where it can be protected from malaria by controlling aquatic stages of mosquitoes. Rigorous but affordable and scaleable methods for mapping [...] identification and inclusion of these key areas, as well as more equal distribution of the workload of malaria control field staff. CONCLUSIONS: The procedure developed enables complete coverage of targeted areas [...] affordable, and requires minimal technical skills. This approach...
Country planning for health interventions under development: lessons from the malaria vaccine decision-making framework and implications for other new... (Publications)
development will be supported by data (e.g. malaria disease burden; roles of other malaria interventions; malaria vaccine impact; economic and financial issues; malaria vaccine efficacy, quality and safety) [...] paper describes research into the anticipated processes and data needed to inform decision making on malaria vaccines, the most advanced of which is still in phase 3 trials. From 2006 to 2008, a series of country [...] consultations in Africa led to the development of a guide to assist...
Molecular approaches to epidemiology and clinical aspects of malaria (Publications)
young children. Fundamental to the development of new tools for malaria control in humans is an increased understanding of key features of malaria infection, such as the diversity of outcome in different i [...] increase our understanding of the epidemiology and clinical manifestations of malaria, as discussed at the Molecular Approaches to Malaria conference (MAM2000), Lorne, Australia, 2-5 February 2000 [...] Malaria is a problem of global importance, responsible for 1-2 million deaths per...
