Mathematical modelling of the impact of expanding levels of malaria control interventions on <em>Plasmodium vivax</em> (Publications)
Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies
Antagonistic effects of <em>Plasmodium</em>-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire (Publications)
INTRODUCTION: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter t
Measuring and characterizing night time human behaviour as it relates to residual malaria transmission in sub-Saharan Africa: a review of the... (Publications)
broad categories: when and where people are exposed to malaria vectors and what people are doing at night that may increase their contact with malaria vectors. Among studies that quantified human-vector [...] BACKGROUND: Malaria cases and deaths decreased dramatically in recent years, largely due to effective vector control interventions. Persistence of transmission after good coverage has been achieved with [...] , namely insecticide-treated nets or indoor residual spraying, poses a...
Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial Guinea (Publications)
donations, followed by Plasmodium malariae (15.3%, 9/59) and Plasmodium ovale (3.4%, 2/59). CONCLUSIONS: This study confirms that in malaria endemic settings, sub-patent malaria infections among blood donors [...] ansmitted malaria are nucleic acid-based molecular approaches such as quantitative polymerase chain reaction. The study was undertaken to determine the prevalence of sub-microscopic malaria parasite infection [...] collected from healthy donors living in Malabo, P. falciparum, P. malar...
Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola (Publications)
The density of malaria parasites is a key determinant in whether or not an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well-studied, there is [...] latent-class modeling to attribute malaria etiology to the fevers and to estimate the sensitivity and specificity of different antigen thresholds for detecting malaria fevers. Amongst patients positive [...] febrile HRP2+ patients compared to afebrile HRP2+ patients. When considering HRP2...
Rapid multiplex gene expression assays for monitoring metabolic resistance in the major malaria vector <em>Anopheles gambiae</em> (Publications)
BACKGROUND: Metabolic resistance of the major malaria vector Anopheles gambiae (s.l.) to insecticides is operationally significant, particularly in combination with target site resistance. However, detection
Single-dose tafenoquine to prevent relapse of <em>Plasmodium vivax</em> malaria (Publications)
BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical
Structure–activity relationship studies and <em>Plasmodium</em> life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl... (Publications)
Structure-activity relationship studies involving N-aryl-3-trifluoromethyl pyrido[1,2-a] benzimidazoles (PBI) identified several compounds possessing potent in vitro activities against the asexual blo
Early antischistosomal leads identified from<em> in vitro</em> and<em> in vivo</em> screening of the Medicines for Malaria Venture pathogen box (Publications)
Facing an almost dry drug development pipeline, screening the Pathogen Box from the Medicines for Malaria Venture (MMV), provides a unique opportunity to possibly expand the pool of potent molecules against