Meta-analysis identifies seven susceptibility loci involved in the atopic march (Publications)
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage
Pharmacological effects of primaquine ureas and semicarbazides on the CNS in mice and antimalarial activity in vitro (Publications)
New primaquine (PQ) urea and semicarbazide derivatives 1-4 were screened for the first time for CNS and antimalarial activity. Behavioural tests were performed on mice. In vitro cytotoxicity on L-6 ce
The elderly, the young and the pregnant traveler - a retrospective data analysis from a large Swiss Travel Center with a special focus on malaria... (Publications)
BACKGROUND: Vulnerable individuals such as elderly, children/adolescents and pregnant/breastfeeding women increasingly travel overseas. We describe the travel and vaccination patterns of these groups
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a s
Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the dise
Antiprotozoal effect of <em>Artemisia indica</em> extracts and essential oil (Publications)
Diverse solvent extracts of Artemisia indica leaves originating from the West Bengal region (India) were assessed for the content of artemisinin and characteristic Artemisia polymethoxyflavonoids, nam
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
Background The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children.
Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy (Publications)
OBJECTIVE: We conducted a community survey to estimate the prevalence and describe the features, risk factors, and consequences of convulsive status epilepticus (CSE) among people with active convulsi
