Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders II (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/further-development-of-simulations-of-plasmodium-falciparum-interventions-and-their-integration-with-the-needs-of-stakeholders-ii
models for predicting the effects of different malaria interventions. It is centered on contributions to the multi-group Bill and Melinda Gates Foundation Malaria Modeling Consortium (MMC). Specific areas [...] e of malaria, of residual transmission, of prioritization and targeting of interventions, and modeling of surveillance-response systems. One important tool used in the project is the OpenMalaria open source [...] including analyses of health systems, pharmacodynamics, and entomological...
Analysis and mapping of prospective sources of funding for additional contributions to MEMTI (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/analysis-and-mapping-of-prospective-sources-of-funding-for-additional-contributions-to-memti
The Global Fund to Fight AIDS, Tuberculosis and Malaria set aside funding to incentivize the acceleration of efforts towards elimination of malaria in four countries in the Asia-Pacific region: Papua New [...] New Guinea, Solomon Islands, Vanuatu and Timor-Leste. This "Malaria Elimination in Melanesia and Timor-Leste Initiative" (MEMTI) is additional to Global Fund country funding allocations and is intended [...] development partners. Regarding the identification of all sources of funding for...
MATIAS (Page)
https://www.swisstph.ch/de/about/med/medicines-implementation-research/matias
for treatment of severe malaria caused by Plasmodium falciparum . These results with high quality evidence led to a change in the WHO guidelines for the treatment of severe malaria in children and adults [...] Key Project | MATIAS Treatment of Severe Malaria with Injectable Artesunate Implementation Non-Controlled Longitudinal Observational Study to Support Artesunate Introduction in the Democratic Republic [...] the Congo (DRC) In 2010, the AQUAMAT study demonstrated that, in children, the...
Claudia Daubenberger (People)
https://www.swisstph.ch/de/staff/profile/people/claudia-daubenberger
activities at Swiss TPH Analysis of human cellular immune responses to P. falciparum malaria antigens and in malaria vaccine trials Analysis of human cellular immune responses in M. ulcerans infection [...] falciparum Characterisation of cellular immune system of Aotus nancymaae, a nonhuman animal model for malaria vaccine development.
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG [...] significantly different between the children who developed severe malaria and those who remained healthy during an observation period of two malaria transmission seasons. However, elevated levels of IgG1 in relation [...] protection from severe malaria (P = 0.02). Conversely, elevated levels...
Status febrilis mit Bewusstlosigkeit (Publications)
Cerebral malaria with Plasmodium vivax is uncommon. Normally Plasmodium falciparum is the cause of cerebral malaria. We report about a 18 year old patient from Pakistan with a history of intermittent fever [...] several months. The patient recovered within a few days; however prognosis can be severe when cerebral malaria is complicating the course of Plasmodium vivax infection
CALINA Study Shows Positive Efficacy and Safety Data for a Novel Treatment for Small Babies (News)
https://www.swisstph.ch/de/news/news-detail-1/news/calina-study-shows-positive-efficacy-and-safety-data-for-a-novel-treatment-for-babies
Malaria exerts a massive burden on public health across the world, particularly in Africa. Huge strides have been made in recent decades in the treatment of malaria. However, to date, little data has been [...] – babies less than 5 kg. Closing the malaria treatment gap The CALINA study is led by Novartis, with the scientific and financial support of Medicines for Malaria Venture (MMV), and as part of the PAMAfrica [...] in babies under 5kg. Infants under 5 kg can be affected by placental malari...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Assessment of Anopheles stephensi surveillance needs, practices and priorities in Global Fund-supported countries in the Horn of Africa (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/assessment-of-anopheles-stephensi-surveillance-needs-practices-and-priorities-in-global-fund-supported-countries-in-the-horn-of-africa
efficient malaria vector, particularly in urban environments, appearing to quickly adapting itself to the local environment and surviving extremely high temperatures during the dry season, when malaria transmission [...] across sub-Saharan Africa, led the World WHO Global Malaria Programme to publish a vector alert noting the major potential threat the vector poses to malaria control and elimination in sub-Saharan Africa. The [...] In recent years, An. stephensi , an efficient urban malaria...