Global diversity and balancing selection of 23 leading <em>Plasmodium falciparum </em>candidate vaccine antigens (Publications)
leading vaccine candidate antigens of P. falciparum using the MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 malaria endemic countries. A stringent variant calling pipeline [...] genes encoding 23 leading and novel candidate malaria vaccine antigens including csp, trap, eba175, ama1, rh5, and CelTOS. Our analysis shows that current malaria vaccine formulations are based on rare haplotypes [...] Investigation of the diversity of malaria parasite antigens can...
High sensitivity detection of <em>Plasmodium</em> species reveals positive correlations between infections of different species, shifts in age... (Publications)
Plasmodium vivax and Plasmodium malariae. The development of a high-throughput molecular species diagnostic assay now enables routine PCR-based surveillance of malaria infections in large field and in [...] falciparum, P. vivax, P. malariae and Plasmodium ovale were observed in LDR-FMA compared to LM diagnosis (p < 0.001). Increases were particularly pronounced for P. malariae (3.9% vs 13.4%) and P. ovale [...] molecular diagnosis reveals patterns of malaria risk that are significantly...
Till Voss (People)
https://www.swisstph.ch/de/staff/profile/people/till-voss
Till Voss, Unit Head, Malaria Gene Regulation (MPI) Till Voss is the Deputy Head of the Medical Parasitology and Infection Biology Department and leads the Malaria Gene Regulation Unit at Swiss TPH. He [...] that drive antigenic variation and sexual commitment in malaria parasites. Further activities include studies on gametocyte biology and malaria transmission-blocking drug discovery. Voss obtained his MSc
Manuel Hetzel (People)
https://www.swisstph.ch/de/staff/profile/people/manuel-hetzel
research, and impact evaluations, with a focus on malaria. Dr. Hetzel’s current work includes investigating and improving the effectiveness of malaria control measures, such as vector control, case management [...] artesunate as pre-referral treatment of severe malaria in children in rural DR Congo, Nigeria and Uganda and conducted studies on the effectiveness of malaria reactive case detection in Zanzibar (Tanzania) [...] (Tanzania). Since 2008, he has been supporting the National Malaria...
Medicines Implementation Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/de/about/med/miru
Treatment of severe Malaria The serious disease malaria is a major burden in tropical and subtropical countries. Although great efforts have been made to control and eliminate malaria, more than 400,000 [...] Rectal Artesunate for Malaria Many children suffering from severe malaria live in poor rural communities with no access to health care. Where parenteral treatment of severe malaria is not available, the [...] Artesunate to Treat Severe Malaria The serious disease malaria is a high burden in...
Reduction in the proportion of fevers associated with <em>Plasmodium falciparum</em> parasitaemia in Africa: a systematic review (Publications)
BACKGROUND: Malaria is almost invariably ranked as the leading cause of morbidity and mortality in Africa. There is growing evidence of a decline in malaria transmission, morbidity and mortality over the [...] presenting with a syndrome of 'presumptive malaria', 3) numerators (number of parasitologically confirmed cases) and denominators (total number of presumptive malaria cases) available, 4) good quality microscopy [...] However, there is still doubt whether this decline is reflected in a...
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resistance in malaria vectors. The aim of this study [...] resistance in malaria vectors, while people's knowledge about insecticide resistance was limited. There is a need to raise awareness in communities about the presence of resistance in malaria vectors and [...] study was to investigate KAPB related to insecticide resistance in malaria...
The empirical support for the radical cure strategy for eliminating <em>Plasmodium vivax</em> in China (Publications)
China is malaria-free, it is timely to consider how elimination of malaria was completed in People's Republic of China over the last 7 decades. Of the four widespread species of human malaria, Plasmodium [...] planning disease elimination in other malaria-endemic countries, with residual P. vivax malaria. METHODS: We collated data from both published and unpublished malaria parasite inoculation experiments conducted [...] (late spring) seasons had a pronounced effect on outbreaks during the mala...
Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
of the 21 children with clinical malaria had pyrimethamine-resistant parasites. Currently, sulfadoxine-pyrimethamine is considered a potential first-line drug for malaria treatment in most African countries [...] used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. The method is based on the observation that [...] suggest that although sulfadoxine-pyrimethamine could still be effective...
Clinical Immunology (Page)
https://www.swisstph.ch/de/about/mpi/clinical-immunology
Nele von Planta Selected Projects EGMVI - Equatorial Guinea Malaria Vaccine Initiative MAL067 - MAL067 - Studies towards understanding RTS,S malaria vaccine induced protection SNF_FP_modelling - Multi-scale [...] development of novel drugs against malaria. Lancet Infect Dis . 2022;22:753-754. DOI: 10.1016/S1473-3099(21)00679-4 Daubenberger C. Assessment of experimental malaria vaccine induced protection in pre-exposed [...] well as host factors elicited by subunit and whole parasite vaccines...