Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
New Antimalarial Drug Shows Promise (News)
https://www.swisstph.ch/de/news/news-detail-1/news/new-antimalarial-drug-shows-promise
Medicines for Malaria Venture (MMV), the Swiss Tropical and Public Health Institute (Swiss TPH) and other international researchers. "The ability of MMV048 to block all life-cycle stages of the malaria parasite [...] history in diseases of poverty. Malaria research has been a core focus since the institute's foundation in 1943. Today, some 200 specialists work on various aspects of malaria in Basel and abroad. Activities [...] parasite from person to person, suggests that this compound could...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately become part of...
Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
Effects of bednet coverage (C) on prevalence of malaria were analysed using data from 1990-92 from 9 Papua New Guinean villages. Effects of coverage varied by age, resulting in a shift in age of peak [...] for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with no bednets the age distribution of P. falciparum parasitaemia was like that [...] mesoendemicity. Thus, protracted use of bednets can result in profound changes in...
Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of <em>Plasmodium falciparum</em>: a feasibility study (Publications)
Genomic epidemiology holds promise for malaria control and elimination efforts, for example by informing on Plasmodium falciparum genetic diversity and prevalence of mutations conferring anti-malarial [...] drug resistance. Limited sequencing infrastructure in many malaria-endemic areas prevents the rapid generation of genomic data. To address these issues, we developed and validated assays for P. falciparum [...] resistance markers. We developed a bioinformatics workflow that allows genotyping...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
The N-terminal domain of <em>Plasmodium falciparum</em> circumsporozoite protein represents a target of protective immunity (Publications)
serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS(65-110)) by sera from children living in a malaria-endemic region was associated with [...] N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice [...] from disease. Taken together, these results underline the...
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...