Whole-genome sieve analysis: identification of protective malaria antigens by leveraging allele-specific vaccine efficacy (Publications)
Discovery of new protective malaria antigens will enable the development of novel vaccine formulations with potentially higher efficacy. While several high-throughput experimental approaches enable the
The interspecific competition between larvae of <em>Aedes aegypti</em> and major african malaria vectors in a semi-field system in Tanzania (Publications)
Interspecific competition between mosquito larvae may affects adult vectorial capacity, potentially reducing disease transmission. It also influences population dynamics, and cannibalistic and predato
Contrasting vector competence of three main East African <em>Anopheles</em> malaria vector mosquitoes for <em>Plasmodium falciparum</em> (Publications)
three malaria vector species may contribute to malaria transmission in East Africa, with An. funestus demonstrating superior vector competence. In conclusion, there is a need for comprehensive malaria control [...] control strategies targeting major malaria vector species, an update of malaria transmission models to consider vector competence and evaluation of malaria transmission blocking interventions in assays that [...] majority of malaria transmission, posing a significant public health...
Improving coverage of antenatal iron and folic acid supplementation and malaria prophylaxis through targeted information and home deliveries in Côte... (Publications)
09, p=0.235) for INFO+DELIV. While INFO had no effect on malaria parasitaemia (aPR=0.95, 95% CI 0.39 to 2.31, p=0.915), INFO+DELIV reduced malaria parasitaemia by 83% (aPR=0.17, 95% CI 0.04 to 0.75, p=0 [...] INTRODUCTION: Coverage of antenatal iron and folic acid (IFA) supplementation and malaria chemoprophylaxis remains low in many low-income and middle-income settings. We assessed the effectiveness of personal [...] intermittent preventive treatment in pregnancy (IPTp), and their...
Assessing the variability in experimental hut trials evaluating insecticide-treated nets against malaria vectors (Publications)
Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. The level of variability present in the assay will influence whether
Species composition and insecticide resistance in malaria vectors in Ellibou, southern Côte d’Ivoire and first finding of <em>Anopheles... (Publications)
status of the target vector population is important to guide malaria vector control. The aim of this study was to characterize the malaria vector population in terms of species composition, insecticide [...] an early warning sign, as An. arabiensis shows a different biology than the currently documented malaria vectors. Because the local An. gambiae population was still susceptible to malathion, upregulation
The relative effect of climate variability on malaria incidence after scale-up of interventions in western Kenya: a time-series analysis of monthly... (Publications)
effect of climate variability on malaria incidence after scale-up of interventions in western Kenya. Methods Bayesian negative binomial models were fitted to monthly malaria incidence data, extracted from [...] variable selection was used to determine the elapsing time between climate suitability and malaria incidence. Results Malaria incidence increased by 50% from 2008 to 2010, then declined by 73% until 2015. There [...] associated with a decline in malaria incidence in children aged 6–59...
Modelling to inform next-generation medical interventions for malaria prevention and treatment (Publications)
Global progress against malaria has stagnated and novel medical interventions to prevent malaria are needed to fill gaps in existing tools and improve protection against infection and disease. Candidate [...] opportunity to link product characteristics with expected public health outcomes. Population models of malaria transmission can provide a better understanding of which, and at what magnitude, key intervention [...] deployment strategies. We describe how modelling evidence can guide and...
