Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent... (Publications)
Surveillance programmes often use malaria rapid diagnostic tests (RDTs) to determine the proportion of the population carrying parasites in their peripheral blood to assess the malaria transmission intensity. Despite [...] quality control activities for RDTs deployed in malaria surveillance programmes. Methods: The diagnostic performance of field-deployed RDTs used for malaria surveys was assessed by retrospective molecular [...] P. falciparum histidine rich protein 2 (PfHRP2) antigen...
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study (Publications)
ted BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults. CONCLUSIONS: A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African [...] we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients. RESULTS: RTS,S/AS01 vaccination was associated [...] month 3 levels correlated with malaria risk. In contrast, baseline levels...
Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea (Publications)
Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support a transition to spatially targeted interventions for malaria elimination [...] spatial heterogeneity of malaria risk and investigate the contribution of individual, household and environmental-level risk factors. Following a period of declining malaria prevalence, the prevalence [...] useful indicators of transmission hotspots and inform the development of tailored...
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for <em>Plasmodium falciparum </em>malaria transmission research (Publications)
The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and [...] In summary, we believe the iGP approach developed here will greatly expedite basic and applied malaria transmission stage research.
Evaluation of different deployment strategies for larviciding to control malaria: a simulation study (Publications)
METHODS: A malaria transmission model, OpenMalaria, was used to simulate varying larviciding strategies and their impact on host-seeking mosquito densities, entomological inoculation rate (EIR) and malaria prevalence [...] BACKGROUND: Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary [...] g were simulated for three transmission intensities and four...
Analysis of contamination in cluster randomized trials of malaria interventions (Publications)
BACKGROUND: In cluster randomized trials (CRTs) of interventions against malaria, mosquito movement between households ultimately leads to contamination between intervention and control arms, unless they [...] which contamination measurably biases the estimate of effectiveness. A sigmoid function is fitted to malaria prevalence or incidence data as a function of the distance of households to the intervention boundary
Transfluthrin eave-positioned targeted insecticide (EPTI) reduces human landing rate (HLR) of pyrethroid resistant and susceptible malaria vectors in... (Publications)
of transfluthrin eave-positioned targeted insecticide (EPTI) depends on the resistance status of malaria vectors. METHODS: Ribbons treated with 5.25 g transfluthrin or untreated controls were used around
