Case report: Diagnostic challenges in the detection of a mixed <em>Plasmodium vivax/ovale</em> infection in a non-endemic setting (Publications)
In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the [...] This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation
Disease Modelling and Intervention Dynamics | Swiss TPH (Page)
https://www.swisstph.ch/de/about/eph/disease-modelling/disease-modelling-and-intervention-dynamics
penny@unibas.ch Links Malaria Modelling Resource Centre Key Projects Shaping Next-Generation Interventions for Malaria Prevention Despite progress to reduce malaria burden, malaria parasites are becoming [...] Selected Projects All Projects Mathematical models to define new malaria immunotherapies and interventions to meet public health needs Core Malaria Modelling Mathematical modelling to examine disease, control [...] to address contemporary issues in infectious diseases and global health. We...
Infection Biology and Molecular Epidemiology | Swiss TPH (Page)
https://www.swisstph.ch/de/infection-biology-and-molecular-epidemiology
infectious diseases. In the field of the life sciences, Swiss TPH places particular emphasis on malaria, tuberculosis and other poverty-related infectious diseases. We use state-of-the-art basic research [...] of new drugs, diagnostics and vaccines. Helminths HIV/AIDS Human African Trypanosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis
New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic... (Publications)
INTRODUCTION: The decline of malaria and scale-up of rapid diagnostic tests calls for a revision of IMCI. A new algorithm (ALMANACH) running on mobile technology was developed based on the latest evidence [...] (387%) in control arm were diagnosed with an infection in need for antibiotic, while 38% and 96% had malaria. 815/838 (973%;961-98.4%) were cured at D7 using ALMANACH versus 573/623 (920%;898-941%) using standard
Spatial epidemiology of urban health risks in select West African cities (Publications)
epidemiology of diarrhaea and malaria, and their associated risks factors in the following select West African cities. Spatial variability of exposure to diarrhaea and malaria transmission is linked to several
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.
Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Spatial risk profiling of <em>Plasmodium falciparum</em> parasitaemia in a high endemicity area in Côte d'Ivoire (Publications)
in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level. METHODS: A questionnaire was administered to about 4,000 schoolchildren [...] parasitaemia. After accounting for spatial correlation, age, bed net coverage, rainfall during the main malaria transmission season and distance to rivers remained significant covariates. CONCLUSION: It is argued [...] villages in close proximity to rivers, in concert with other...
Spatial effects of mosquito bednets on child mortality (Publications)
Insecticide treated nets (ITN) have been proven to be an effective tool in reducing the burden of malaria. Few randomized clinical trials examined the spatial effect of ITNs on child mortality at a high [...] coverage. We analyzed for the first time data from a large follow-up study in an area of high perennial malaria transmission in southern Tanzania to describe the spatial effects of bednets on all-cause child mortality [...] with insecticide, and (2) the relative homogeneity of coverage with...