Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Mathematical Epidemiology (Page)
https://www.swisstph.ch/de/about/eph/disease-modelling/mathematical-epidemiology
computational models to improve understanding of population, infection and disease dynamics, focusing on malaria and neglected tropical diseases. Nakul Chitnis PD, PhD Group Leader +41612848242 nakul.chitnis@swisstph [...] 2255061 Das A.M et al. Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania. Nat Commun . 2023;14:2750. DOI: 10.1038/s41467-023-38379-8 Fillinger [...] double-blind placebo-control study assessing the protective...
Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia (Publications)
some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination [...] which, in many countries, plays an important role in the provision of malaria treatment. The Affordable Medicines Facility for malaria (AMFm) is a recent initiative that aims to increase the provision of
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have been [...] six months after the mass distribution. Descriptive statistics were used to measure changes in key malaria household indicators. LLIN ownership and use were compared between delivery strategies. Univariate [...] have a significant impact on LLIN use (69.6% [95% CI 63.1-75.5%] versus 65.7%...
Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category (Publications)
are under-reported in Africa and often mistaken for malaria. These results highlight the need to introduce point-of-care tests, beside the one for malaria, to detect outbreaks and orientate diagnosis. TRIAL [...] clinical presentation, including warning signs, was assessed by logistic regression adjusted for age, malaria coinfection, secondary dengue and duration of symptoms at inclusion. The independent association [...] attended care after a slightly longer duration of symptoms (median of 2.9...
Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used? (Publications)
(ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the global burden of malaria in recent years. While the [...] ITN for 2 people did not exceed 60% at the national level in any survey, except in Uganda's 2014 Malaria Indicator Survey (MIS). At 80% population ITN access, the expected proportion of households with [...] success of an ITN distribution programme. Under current ITN distribution...
Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/further-development-of-simulations-of-plasmodium-falciparum-interventions-and-their-integration-with-the-needs-of-stakeholders
platform for comparing, fitting, and evaluating different individual-based stochastic simulations of malaria epidemiology. Aims In the next phase of the project, we propose to exploit the functionality of this [...] potential clients, and develop capacity to anticipate and react promptly to requests from the R & D and malaria intervention communities.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)
to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disease known to affect hundreds of millions of people and presents a perceivable [...] polar oxygen and amidine substituents and the hydrophobic linking chain for the activity against malaria
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and <em>in vivo</em> efficacy in the... (Publications)
SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During [...] Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rgamma(null) (NSG)