Plasmodium vivax Transmission Model (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/plasmodium-vivax-transmission-model
parasite is dominant. This compartmental model accounts specifically for the liver stages of P. vivax malaria and it has recently been refined to include imported infections as well as treatment of blood and/or [...] data on reported local and imported cases, and it can be used to simulate the expected impact of malaria treatment schemes, vector control strategies, reactive interventions or mass drug administration
Fast-killing tyrosine amide ((<em>S</em>)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance... (Publications)
Current malaria treatments are threatened by drug resistance, and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with [...] fast-killing mechanism of action, available for lead optimization to generate new treatments for malaria.
Plasmodium vivax Transmission Model (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/plasmodium-vivax-transmission-model
parasite is dominant. This compartmental model accounts specifically for the liver stages of P. vivax malaria and it has recently been refined to include imported infections as well as treatment of blood and/or [...] data on reported local and imported cases, and it can be used to simulate the expected impact of malaria treatment schemes, vector control strategies, reactive interventions or mass drug administration
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
A simple and efficient tool for trapping gravid <em>Anopheles</em> at breeding sites (Publications)
BACKGROUND: No effective tool currently exists for trapping ovipositing malaria vectors. This creates a gap in our ability to investigate the behavior and ecology of gravid Anopheles. FINDINGS: Here we [...] ecology of gravid female Anophelines. It strongly implies that at least two of the major vectors of malaria in Africa land on the water surface during the oviposition process, and demonstrates that Anophelines
Combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an... (Publications)
BACKGROUND: On-going malaria transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are [...] dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a malaria endemic village in Tanzania, where vectors had lost susceptibility to pyrethroids. MLBs with three
Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity (Publications)
artemisinin is an important antimalarial drug and the herb itself is being grown and used locally for malaria treatment although this practice is controversial. Here we show that the ancient Chinese methods [...] in P. berghei infected mice. The implications of these results are discussed in the context of malaria treatment using A. annua infusions
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/de/research/basic-research-in-infection-biology
so-called neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium that are t [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty including Malaria (caused by Plasmodium spp .), Tuberculosis (caused by Mycobacterium tuberculosis ), Buruli ulcer [...] Mycobacterium ulcerans ) and Sleeping sickness, African trypanosomiasis (caused...
Basel vaccine research and development initiative (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/basel-vaccine-research-and-development-initiative
tropics by addressing current needs in vaccines research and development. First targets will be malaria and Buruli ulcer, two infectious diseases which affect primarily children in Africa.