The <em>Plasmodium </em>lactate/H+ transporter PfFNT is essential and druggable <em>in vivo</em> (Publications)
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l-lactate/H(+) from the cell. This transporter is a member of the strictly [...] ty of the PfFNT target on a genetic level, and established its in vivo druggability using mouse malaria models. We found that, besides a previously identified PfFNT G107S resistance mutation, selection
Life expectancy of <em>Anopheles funestus</em> is double that of <em>Anopheles arabiensis</em> in southeast Tanzania based on mark-release-recapture... (Publications)
stricto mosquitoes are major East African malaria vectors. Understanding their dispersal and population structure is critical for developing effective malaria control tools. Three mark-release-recapture
Kurse in Diagnostik (Page)
https://www.swisstph.ch/de/activities/diagnostic-centre/courses-in-diagnostic
Parasitologie, die regelmässig am Swiss TPH stattfinden. Die Kurse befassen sich mit der Diagnostik von Malaria, Darmprotozoen oder Helminthen. Course Coordination Peter Odermatt Contact Rachel Gutknecht Ursina
Diaryl ureas as an antiprotozoal chemotype (Publications)
kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models of malaria and toxoplasmosis.
Synthesis of szentiamide, a depsipeptide from entomopathogenic <em>Xenorhabdus szentirmaii</em> with activity against <em>Plasmodium falciparum</em> (Publications)
on of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria
A paradigm for Africa-centric vaccine development in Equatorial Guinea (Publications)
The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development
Aktivitäten (Page)
https://www.swisstph.ch/de/about/events/open-house-2023/activities
TPH: Eine Reise in die Vergangenheit Klinische Forschung: Bringe ein Medikament auf den Markt** Malaria, Tollwut und Gelbfieber: Reisen Sie gesund? Kuscheltier-Spital: Wir machen dein Plüschtier gesund* [...] Seuchen-Detektive: Untersuche einen Krankheitsausbruch** Mückennetz-Labyrinth: Kein Durchkommen für Malaria*/** Von der Wildbahn aufs Papier: Comics Zeichnen mit Fizzi** Tierische Kreativwerkstatt für Kids*
New <em>in vitro</em> interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations (Publications)
The development and spread of drug-resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require [...] will significantly improve and streamline the economic development of new drug combinations for malaria and potentially also in other therapeutic areas.
Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household... (Publications)
(danger signs) in rural communities are crucial for preventing complications and death from severe malaria, pneumonia, and diarrhea. We set out to determine the treatment-seeking practices and treatment patterns [...] of age with an acute febrile illness, with or without danger signs of severe disease, in a highly malaria-endemic area of northern Uganda. Three household surveys were conducted from November through December
Parasitic infections, anemia and malnutrition among rural settled and mobile pastoralist mothers and their children in Chad (Publications)
Chad. Intestinal parasites were evaluated using direct fecal smears and the Kato-Katz technique. Malaria status was determined using Paracheck-Pf((R)) rapid diagnostic test, and anemia was assessed with [...] common protozoan. The hookworm prevalence was 14% (CI 8-20) in women and 18% (CI 13-23) in children. Malaria prevalence was low among women (1%, CI 0.5-2) and children (3% CI 2-5). No significant difference