Prevalence of malaria across Papua New Guinea after initial roll-out of insecticide-treated mosquito nets (Publications)
samples were collected from all consenting household members for microscopic diagnosis of malaria. RESULTS: Malaria prevalence ranged from 0% to 49.7% with a weighted average of 12.1% (95% CI 9.5, 15.3) in [...] 0.001). Splenomegaly in children and anaemia were common morbidities attributable to malaria. CONCLUSIONS: Malaria prevalence across PNG is again at levels comparable to the 1970s. The strong association [...] OBJECTIVES: To assess the population prevalence of malaria in villages across...
Behavioural determinants of gene flow in malaria vector population: <em>Anopheles gambiae</em> males select large females as mates (Publications)
transgenic vectors. Fundamental studies of behavioural ecology in malaria vectors such as An. gambiae can have important implications for malaria control and should be prioritised for more extensive investigation [...] BACKGROUND: Plasmodium-refractory mosquitoes are being rapidly developed for malaria control but will only succeed if they can successfully compete for mates when released into the wild. Pre-copulatory [...] structure in wild mosquito populations and mating barriers have foiled...
Three different <em>Plasmodium</em> species show similar patterns of clinical tolerance of malaria infection (Publications)
data on the age dependence of tolerance in other species of human malaria. METHODS: Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New [...] to the logarithm of the parasite density for all three malaria species, with little age variation in the relationship for P. vivax or P. malariae. P. falciparum shows more age variation in disease incidence [...] BACKGROUND: In areas where malaria endemicity is high, many people...
Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data (Publications)
People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymorphic
The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in... (Publications)
BACKGROUND: Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure that [...] attitudes or adherence to the expanded programme on immunisation (EPI) or treatment seeking or existing malaria prevention. CONCLUSION: In order to improve adherence to both EPI and IPTi local priorities should
Allomonal effect of breath contributes to differential attractiveness of humans to the African malaria vector Anopheles gambiae (Publications)
contributes to between-person differences in relative attractiveness to the highly anthropophilic malaria vector Anopheles gambiae sensu stricto remains unknown and was the focus of the present study. METHODS: [...] contributor to between-person differences in the relative attractiveness of humans to this important malaria vector
Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity (Publications)
Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect malaria epidemiology. The [...] heterogeneity were incorporated into a comprehensive individual-based model of Plasmodium falciparum malaria epidemiology. The different types of heterogeneity were systematically simulated individually, and
Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
seasonality, proportions of malaria fevers treated and drug characteristics. METHODS: We use a dynamic, individual-based simulation model of Plasmodium falciparum malaria epidemiology, antimalarial drug [...] preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness. The effects of different intervention [...] g and more expensive drugs, high frequencies of drug resistance and high levels...
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
developed severe malaria while 6/137 of both RDT and BS positive did so. The use of RDT allowed a reduction of a median of 2.1 hours to get a first malaria test result.CONCLUSIONS: A malaria diagnostic strategy [...] tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diagnose falciparum malaria based on [...] those, 2/2028 (0.1%) developed uncomplicated malaria with both RDT and BS...
Experience and challenges from clinical trials with malaria vaccines in Africa (Publications)
clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, [...] Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort [...] Despite this, there is currently no licensed malaria vaccine. Researchers,...
