Genome-wide analysis of variations in Plasmodium falciparum parasites population and their impact on different malaria interventions in Tanzania (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/genome-wide-analysis-of-variations-in-plasmodium-falciparum-parasites-population-and-their-impact-on-different-malaria-interventions-in-tanzania
Malaria affects millions of people globally, and the disease remains one of the major public health problems occurring in most parts of the world, causing thousands of deaths each year, especially among
Exploring early sexual differentiation in the malaria parasite Plasmodium falciparum (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/exploring-early-sexual-differentiation-in-the-malaria-parasite-plasmodium-falciparum
Apicomplexa, is the causative agent of the most severe form of malaria in humans. Despite the massive implementation of control interventions, malaria still causes over 200 million clinical cases and half a million [...] million deaths annually. The widespread prevalence of malaria in endemic regions is maintained by a complex yet highly efficient transmission cycle between the human host and mosquito vector. For transmission [...] gametocyte biology will be essential to support the development...
Combining sociological, economic and epidemiological evidence to target malaria interventions in Papua New Guinea and beyond (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/combining-sociological-economic-and-epidemiological-evidence-to-target-malaria-interventions-in-papua-new-guinea-and-beyond
interventions. However, current recommendations focus exclusively on stratification by malaria risk. Yet, malaria is multi-factorial and the impact of interventions in a given setting also depends on [...] conceptual framework for a multi-dimensional malaria stratification beyond mere epidemiological indicators. Papua New Guinea (PNG) with its complex malaria epidemiology serves as a model country. Project [...] To improve the (cost-) effectiveness of malaria control and accelerate progress...
Environmental, Social, Economic and Health Impact Assessment (ESHIA) for a Field Study of a Self-Limiting Nondrive Strain of Genetically Modified... (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/environmental-social-economic-and-health-impact-assessment-eshia-for-a-field-study-of-a-self-limiting-nondrive-strain-of-genetically-modified-mosquitoes-on-behalf-of-target-malaria
Genetically modified mosquitoes (GMMs) represent great potential for malaria control in the future. Target Malaria – a vector control research alliance based at the Imperial College in London – aims to [...] develop genetic technologies to modify mosquitoes with the ultimate goal to reduce malaria transmission. Target Malaria uses a three-phased approach in this 170-million project funded by the Bill and Melinda
Deciphering Environmental Sensing in Malaria Parasites (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/deciphering-environmental-sensing-in-malaria-parasites
The Malaria Host Interactions Unit (MHIU) is studying the molecular interface between malaria parasites and their human host. Recent findings revealed the existence of intimate links between parasite [...] inducing specific transcriptional responses. This capability is surprising in light of the fact that malaria parasites have lost canonical nutrient sensing pathways present in other eukaryotic organisms. With
Core Malaria Modelling (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....
Towards Elimination of Malaria in Tanzania (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/towards-elimination-of-malaria-in-tanzania
Malaria and poverty entertain a close relationship through historical times. Past studies have abundantly documented the benefits of malaria control on economic development and human well-being, and as [...] of malaria across the country declined, the heterogeneity in transmission greatly increased. At present, some areas in Tanzania remain with a very high transmission and hence with a high malaria burden [...] and risk stratification followed by decentralized malaria control planning has...
Mathematical models to define new malaria immunotherapies and interventions to meet public health needs (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/mathematical-models-to-define-new-malaria-immunotherapies-and-interventions-to-meet-public-health-needs
progress in fighting malaria, there remains a need for new antimalarial interventions to protect children and other vulnerable populations who experience the highest burden of malaria. Developing new in [...] from academia, product development partners, and representatives from malaria-endemic countries. Our focus is on next-generation malaria vaccines, monoclonal antibodies, and new chemoprevention antimalarials
The useful life of bednets for malaria control in Tanzania: Attrition, Bioefficacy, Chemistry, Damage and Insecticide Resistance. (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/the-useful-life-of-bednets-for-malaria-control-in-tanzania-attrition-bioefficacy-chemistry-damage-and-insecticide-resistance
life of bednets for malaria control in Tanzania: Attrition, Bioefficacy, Chemistry, Damage and insecticide Resistance. Long-Lasting Insecticidal Nets (LLINs) are the front line malaria vector control tool [...] practice for the maintenance of high and cost-effective coverage and to maximise current gains in malaria control. We will make the data available to stakeholders including NMCP and their collaborators:
Understanding heterogeneities in the epidemiology of malaria in Papua New Guinea (Projects)
https://www.swisstph.ch/de/projects/project-detail/project/understanding-heterogeneities-in-the-epidemiology-of-malaria-in-papua-new-guinea
Background Malaria has been endemic across most parts of Papua New Guinea (PNG) at endemicity levels comparable to sub-Saharan Africa. The National Malaria Control Program (NMCP) has managed to substantially [...] impact of malaria control interventions and underlying secular trends. Drivers of change, and reasons for differences between sites will be investigated. 2) Geo-referenced data on clinical malaria cases will [...] ongoing mathematical modelling of heterogeneities in malaria dynamics at...